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CH. V. Ramana Devi M. P. J. S. Anandaraj 《Indian journal of clinical biochemistry : IJCB》1994,9(1):21-23
The enhanced presence of calcium in the erythrocytes of thalassemia homozygotes along with an increase in cytosolic and membrane
bound CANP, and a decrease in membrane glycoprotein and total membrane sulfhydryl groups are statistically significant changes.In vitro loading of erythrocytes with calcium in the presence of lonophore A23187 caused similar changes pointing to the significance of calcium mediated proteolysis, especially by CANP in preparing erythrocytes
for the phagocytic event. 相似文献
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Rahul A. Ghone K. M. Kumbar A. N. Suryakar R. V. Katkam N. G. Joshi 《Indian journal of clinical biochemistry : IJCB》2008,23(4):337-340
Repeated blood transfusion in beta thalassemia major patients may lead to peroxidative tissue injury by secondary iron overload.
In the present study, 72 children with beta thalassemia major were included. Serum levels of total lipid peroxides, Iron,
Total Iron Binding Capacity, Copper, Zinc, Vitamin E, plasma Total Antioxidant Capacity, activity of Erythrocyte Superoxide
Dismutase, were measured. The findings were compared with 72 age matched healthy controls irrespective of sex. A significant
increase in the levels of lipid peroxide and Iron (p<0.001), whereas, significant decrease in the levels of vitamin-E, Total
Antioxidant Capacity and Total Iron Binding Capacity (p<0.001) was observed. Serum Zinc was significantly increased (p<0.001)
with significant decrease in the levels of copper (p<0.001). Non Significant increase in the activity of Erythrocyte Superoxide
Dismutase (p>0.05) was found in the patients when compared with controls. This suggest that oxidative stress and reduced antioxidant
defense mechanism play an important role in pathogenesis of beta thalassemia major. 相似文献
3.
Membrane lipid and protein composition was compared in erythrocytes from iron deficiency anemia (IDA) and heterozygous beta
thalassemia patients. The study was planned to correlate the influence of iron deficiency with the intrinsic defect of the
heterozygous condition on the membrane structural integrity as well as to investigate whether there are differences in membrane
changes between the two conditions. Results indicate high levels of saturated fatty acids and low unsaturated fatty acids
in both disorders although arachidonic acid and the unsaturation index were lower in heterozygous thalassemia than IDA. Nevertheless,
neither of the conditions provoked any alterations in membrane protein or glycophorin suggesting alterations in the lipid
moiety only. Present findings indicate that irrespective to the etiology, both, iron deficiency and the heterozygous condition
show a common pattern of lipid derangement, which may in turn result in increased membrane rigidity and decreased cellular
deformability. 相似文献
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Phenotypic Heterogeneity of Asian Indian Inversion Deletions Gγ(Aγδβ)0 Breakpoint A and Breakpoint B
Sanjay Pandey Sweta Pandey Ravi Ranjan Rahasyamani Mishra Monica Sharma Renu Saxena 《Indian journal of clinical biochemistry : IJCB》2013,28(1):98-101
Asian Indian inversion deletion Gγ (Aγδβ)0-thalassemia is a rare entities characterized by high HbF. Due to interaction with various genetic factors, patients with Gγ (Aγδβ)0-thalassemia showed clinical variability. Here we are presenting the phenotypic expression of Gγ(Aγδβ)0 thalassemia under influence of various co-inherited factors. Patient with α-globin gene deletion had mild phenotype than the patient with β-globin mutations. Patient with alpha gene deletion were presenting clinical character like thalassemia intermedia while Gγ (Aγδβ)0-thalassemia patients with co- presence of beta thalssemia mutation clinically behaved like thalassemia major. 相似文献
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