肌肉因子Irisin与运动     

林文弢  鞠丽丽  吴菊花  翁锡全 《广州体育学院学报》2016,(1):87-90

Irisin是新近在骨骼肌中发现的肌肉因子,可促进白色脂肪细胞棕色化,增加能量消耗、降低体重.运动通过影响Irisin、UCP1的表达来调控脂代谢进而改善肥胖、糖尿病等代谢性疾病,但不同运动方式和运动强度对Irisin表达的影响规律并不相同.将深入探讨运动调控lrisin表达变化的作用机制,旨为防治肥胖等代谢性疾病提供新视角.  相似文献   

Acute exercise-induced irisin release in healthy adults: Associations with training status and exercise mode     

Shanhu Qiu  Edit Bosnyák  Gunnar Treff  Jürgen Michael Steinacker  Andreas Michael Nieß  Karsten Krüger 《European Journal of Sport Science》2018,18(9):1226-1233

There is a growing interest in exploring irisin response to acute exercise; however, the associations of acute exercise-induced irisin release with training status and exercise mode are not fully understood. This study was primarily designed to evaluate these associations. Sixteen healthy adults (8 trained versus 8 untrained) underwent a bout of cycling at 80% of maximal oxygen uptake (VO_2max) for 50?min, with blood drawn pre-, 10-, and 180-min post-exercise. Another 17 healthy adults performed 2 bouts of graded exercise (cycling and running) until exhaustion on separate days using a randomized cross-over design, with blood taken pre-, 0-, 10-, and 60-min post-exercise. Circulating irisin, creatine kinase (CK), aspartate aminotransferase (AST), and myoglobin (Mb) were measured, and their respective areas under the curves (AUCs) were calculated. Irisin increased 10-min after 50?min of cycling at 80% of VO_2max, while its changes from baseline to post-exercise and the amount of exercise-induced irisin release (presented as AUC) were comparable between trained and untrained adults (all P?>?.05). Irisin remained elevated 10-min post-exhausting running but decreased towards baseline 10-min post-exhausting cycling. Exhausting running induced an increase in irisin release for the whole course of exercise and recovery periods, but cycling did not. Acute exercise-induced irisin changes seemed not related to changes of CK, aspartate AST, and Mb in general. In conclusion, acute exercise-induced irisin release is not associated with training status but might be affected by training mode. Future studies are required to investigate which exercise mode might be most efficient in altering irisin.  相似文献