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针对传统医学机能实验教学模式手段单一、教学资源不足、大型综合实验成功率低、教学效果欠佳等问题,将虚拟仿真技术应用于医学机能实验教学,设计开发了血管收缩效能测定和评价虚拟仿真实验。通过该中英文双语版虚拟仿真实验,学生可突破时空限制,利用碎片化时间学习实体实验无法大规模开展的医学机能实验内容,验证所学理论知识,掌握实验操作技能,分析实验数据结果,提高专业英语水平。该虚拟仿真实验在教学中的应用,有效激发了学生的学习兴趣,提高了学生的学习效率和科研创新能力。  相似文献   
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Abstract

In this study, we examined the time course of changes in the blood volume and oxygenation of accessory respiratory (RM) and locomotor (LM) muscles, and the interrelationships of changes in these parameters during maximal incremental intermittent exercise in 15 non-endurance-trained active men. Blood volume and oxygenation of the serratus anterior and of vastus lateralis were measured simultaneously by near-infrared spectroscopy. The respiratory compensation point, and the breakpoints where abrupt changes were apparent in RM and LM blood volume and oxygenation versus time were identified. During exercise, the decreases in RM and LM oxygenation were accentuated in the vicinity of the respiratory compensation point. This was concomitant with a reduction in LM, but not RM, blood volume. The time at which the respiratory compensation point and the breakpoints in RM and LM blood volume and oxygenation were detected (70.2–75.0% exercise time) did not differ, and were inter-correlated (r=0.56 to 0.95). Moreover, the rate of the accelerated fall of oxygenation in the locomotor muscles was correlated with that of the decline in blood volume in that area (r=0.73), and with that of the accelerated fall of oxygenation in the respiratory muscles (r=0.71). The results suggest that the high ventilatory demand, which occurs naturally during intense intermittent exercise in non-endurance-trained individuals, may precipitate an accelerated fall in RM oxygenation, concomitant with a reduction in LM blood volume and an accentuated decline in LM oxygenation. Such responses are likely to occur above the respiratory compensation point during intermittent exercise.  相似文献   
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最大吸氧量中枢限定因素研究的进展   总被引:2,自引:0,他引:2  
心脏泵血能力是VO2max限定因素的观点早已提出,60~70年代此观点受到了肌肉适应性研究结果的挑战。肌肉血管床和线粒体数量随训练可有所增加,这些适应被认为是VO2max提高的前提条件。此后,由于令人信服的研究结果的展示,偏移的观点又回转到心肺机能是氧投递的限定因素上来。  相似文献   
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Exercising in the cold is not an attractive option for many athletes; however, defining what represents cold is difficult and is not standard for all events. If the exercise is prolonged and undertaken at a moderate intensity, environmental temperatures around 11°C can be an advantage. If the intensity is lower than this value and the individual does not generate sufficient metabolic heat to offset the effects imposed by the cold environment, then temperatures of 11°C can be detrimental to performance. Similarly, when the performance involves dynamic explosive contractions, then a cold ambient temperature can have a negative influence. Additional factors such as the exercising medium, air or water, and the anthropometric characteristics of the athlete will also make a difference to the strategies that can be adopted to offset any negative impact of a cold environment on performance. To plan for a performance in the cold requires an understanding of the mechanisms underpinning the physiological response. This review attempts to outline these mechanisms and how they can be manipulated to optimize performance.  相似文献   
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摘要:目的:观察不同强度运动对骨骼肌功能性抗交感活性的影响,并探讨一氧化氮(NO)在其中的作用。方法:45只雄性SD大鼠随机分为安静对照组(C)、中等强度运动组(ME)和高强度运动组(HE),其中C组保持安静状态,ME组进行中等强度、HE组进行高强度跑台运动,共8周。大鼠麻醉后通过电刺激(2 Hz和5 Hz)腰部交感神经诱导血管收缩反应,电刺激(2倍运动阈和5.5倍运动阈)胫神经分别诱发小腿三头肌中等强度和高强度收缩。记录安静状态下以及肌肉收缩过程中交感神经电刺激引发股血管传导性(FVC)的变化,功能性抗交感活性用安静时FVC对交感神经电刺激反应的变化率与肌肉收缩时的差值表示(△%FVC)。结果:1)△%FVC:骨骼肌中等强度收缩,交感神经电刺激为2 Hz时,HE组△%FVC高于C组和ME组(P<0.05);交感神经电刺激为5 Hz时,HE组△%FVC高于C组(P<0.05)。肌肉高强度收缩,交感神经电刺激为2 Hz时,HE组和ME组△%FVC高于C组(P<0.05),HE组△%FVC高于ME组(P<0.05);交感神经电刺激为5 Hz时,HE组和ME组△%FVC高于C组(P<0.05)。2)血浆NO含量:组内与安静时比较,骨骼肌中等强度收缩时和高强度收缩时各组血浆NO含量均升高(P<0.05);与中等强度收缩时比较,高强度收缩时各组血浆NO含量均升高(P<0.05)。组间比较,安静时和中等强度收缩时血浆NO含量在ME组和HE组均高于C组(P<0.05),HE组高于ME组(P<0.05);高强度收缩时血浆NO含量在ME组和HE组均高于C组(P<0.05)。结论:运动可改善骨骼肌功能性抗交感活性并呈现运动强度依赖性,其机制可能与NO介导的信号转导途径诱导血管舒张反应有关。  相似文献   
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