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1.
Lakshmi Lavanya Reddy Swarup A. V. Shah Alpa J. Dherai Chandrashekhar K. Ponde Tester F. Ashavaid 《Indian journal of clinical biochemistry : IJCB》2016,31(1):87-92
Acute coronary syndrome (ACS) is a term for a range of clinical signs and symptoms suggestive of myocardial ischemia. It results in functional and structural changes and ultimately releasing protein from injured cardiomyocytes. These cardiac markers play a major role in diagnosis and prognosis of ACS. This study aims to assess the efficacy of heart type fatty acid binding protein (h-FABP) as a marker for ACS along with the routinely used hs-TropT. In our observational study, plasma h-FABP (cut-off 6.32 ng/ml) and routinely done hs-Trop T (cutoff 0.1 and 0.014 ng/ml) were estimated by immunometric laboratory assays in 88 patients with acute chest pain. Based on the clinical and laboratory test findings the patients were grouped into ACS (n = 41) and non-ACS (n = 47). The diagnostic sensitivity, specificity, NPV, PPV and ROC curve at 95 % CI were determined. Sensitivity of hs-TropT (0.1 ng/ml), hs-TropT (0.014 ng/ml) and h-FABP were 53, 86 and 78 % respectively and specificity for the same were 98, 73 and 70 % respectively. Sensitivity, specificity and NPV calculated for a cut-off combination of hs-TropT 0.014 ng/ml and h-FABP was 100, 51 and 100 % respectively. These results were substantiated by ROC analysis. Measurement of plasma h-FABP and hs-TropT together on admission appears to be more precise predictor of ACS rather than either hs-Trop T or h-FABP. 相似文献
2.
老年妇女从事杨式太极拳前后的某些心功能指标的变化 总被引：6，自引：0，他引：6
对２０名从事杨式太极拳练习１个月的老年妇女进行了心脏结构和功能等指标的测定，结果发现：杨式太极拳可提高老年妇女的心室厚度和收缩幅度，尤其是提高左室后壁厚度和收缩幅度，说明心室壁血波供应得到改善；可使受试者安静时的心率、血压均明显降低，每搏输出量和射血分数均明显升高，揭示老年人从事杨式太极拳练习可改善其心肌血液供应，提高心肌泵血功能。 相似文献
3.
R. Chawla Navendu Goyal Rajneesh Calton Shweta Goyal 《Indian journal of clinical biochemistry : IJCB》2006,21(1):77-82
Early identification of patients with acute myocardial infarction is of prime importance due to the associated very high mortality.
Only 22% of the patients presenting at emergency cardiology care with chest pain have coronary disease. A number of biochemical
tests like CKMB and Troponin-T/I have been introduced for early detection of the coronary syndrome (ACS). Ischemia modified
albumin (IMA) has been recently introduced as a marker of myocardial ischemia. We estimated serum IMA in four sequential samples
from 25 patients admitted to ICCU. Twenty five healthy volunteers formed the control group from which the normal range was
derived. IMA was significantly raised in ischemia patients than in controls as well as compared to the patients who did not
have cardiac ischemia. IMA demonstrated good discrimination between the ischemic and the non-ischemic patients with an Odds
Ratio of 16.9 (6.29–46.87) than CKMB which showed an Odds Ratio of 2.07 (1.18–6.08). Sensitivity and specificity of IMA for
the detection of ACS was 78.0% and 82.7% compared to 58.0% and 60.0%, respectively for the CK-MB assay. The area under the
ROC curve of IMA for ischemic v/s non-ischemic patients was 0.834. IMA appears to be developing into a new and very potent
marker, of cardiac ischemia. 相似文献
4.
V. A. Doss Dharaniyambigai Kuberapandian 《Indian journal of clinical biochemistry : IJCB》2021,36(1):33
The main objective of this study is to evaluate the anti-hypertrophic potential of the aqueous extract of Enicostemma littorale (E. littorale) against isoproterenol induced cardiac hypertrophic rat models (male albino Wistar rats) through biochemical investigations. Aqueous extract of E. littorale known for various beneficial properties was administered (100 mg/kg, 12 days, oral) to isoproterenol (ISO) induced cardiac hypertrophic rats (low ISO—60 mg/kg, 12 days and high ISO—100 mg/kg, 12 days, subcutaneous) and were compared with group that was treated with the reference drug, Losartan (10 mg kg, administered for 12 days, oral). The anti-hypertrophic effect of E. littorale was evaluated by analysing the morphometric indices of the heart, ECG tracings, changes in blood biochemical parameters viz., serum glucose, serum total protein, serum albumin, lipid profile, cardiac specific enzymes (SGOT, SGPT and LDH) and histopathological examination of the heart tissue. The results fundamentally revealed that the plant extract efficiently ameliorated cardiac hypertrophy induced by ISO injected in experimental rats. The outcomes of biochemical investigations of this study highlighted the association between the hypertrophic β-adrenergic receptor signalling (β-AR) and the 5′ AMP-activated protein kinase (AMPK)—peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) axis in the metabolism of cardiac fibrosis and hypertrophy. This β-AR/AMPK-PGC1α signalling stem can serve as a key target in ameliorating cardiac hypertrophy through focus on its principal regulators. To add, we also propose that the glycoside, swertiamarin present in this plant with the reported anti-fibrotic potential in liver can be further isolated and evaluated for its anti-hypertrophic potential to treat cardiac hypertrophy. 相似文献
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用6只牛蛙制备离体蛙心灌流,灌流液中添加1％的茶多酚、茶多糖、红菇多糖50～200μl,结果使蛙心收缩力分别增加84％（40％～169％）、46％（28．6%～70％）、89％（15．4％～289％）（P〈0．05或〈0．01）;三者对蛙心以正性变力作用为主,对心率无显著影响（P〉0．05）。 相似文献
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8.
《European Journal of Sport Science》2013,13(7):737-742
AbstractWith an ageing population there is an increased prevalence of individuals living with cardiovascular disease (CVD). Characteristics of older aerobically fit individuals with previously diagnosed CVD have not been studied. Therefore, our knowledge is limited as to how, or if, aerobically fit individuals with CVD attempt to adapt their physical activity and the intensity of their training programmes. The objective of this paper is to characterise the physical activity habits and behaviours of older aerobically fit individuals with CVD. We identified 28 aerobically fit patients with CVD from those who completed a minimum of 15 and 12 min of the Bruce treadmill protocol for men and women, respectively. Consenting participants responded to questionnaires regarding physical activity levels, competitive event participation and self-monitoring since diagnosis of heart disease. Average age and treadmill time of participants were 56 and 49 years and 15.6 and 13.0 min for males and females, respectively. Data were obtained regarding recent medical history (medical diagnoses, surgeries/procedures). Despite the majority of individuals participating in the same or more activity since their diagnosis, 25% indicated that their condition limited their activity and 39% reported having symptoms during activity. Nearly all participants (93%) indicated that they monitored their heart rate during exercise. However, only 14% of participants stated that their physician advised them on how to exercise safely. It is necessary for physicians and cardiac rehabilitation programmes to be involved in safe and effective exercise programming to allow individuals to return to sport after CVD. 相似文献
9.
E. Jane Green Stuart Biddle Penny Crisfield Roger M. Bartlett N.C. Craig Sharp Adrian Lees 《Journal of sports sciences》2013,31(2):147-158
Clinical sports medicine, Robert C. Cantu, (ed.), The Collamore Press, Lexington, Massachusetts, Toronto, 1984. 219 pp, £19.95 (hb), ISBN 0 669 06842 X Sports injuries, a self‐help guide, Vivian Grisogono, John Murray Ltd, London, 1984. 293 pp, £7.95 (hb), ISBN 0 7195 4111 5 Athletes’ guide to mental training, Robert N. Nideffer, Human Kinetics, Champaign, Illinois (distributed in the UK by Eddington Hook & Co.) 1985. vii +156 pp, $9.95 (pb), ISBN 0 931250 96 X Scientific foundations of coaching, R.R. Pate, B. McClenaghan and R. Rotella, Saunders College Publishing, Philadelphia, 1984. xii + 344 pp, £21.95(hb), ISBN 0 03 057961 9 Mathematics in sport, M. Stewart Townend, Ellis Horwood, Chichester, 1984. 202 pp (hb), ISBN 0 85312 717 4 Frontiers of exercise biology, ’Big Ten Body of Knowledge’ symposium series, Vol. 13 K.T. Borer, D.W. Edington and T.P. White (eds), Human Kinetics Publishers Inc., Champaign, Illinois, (distributed in the UK by Edington Hook & Co.), 1983. vii + 295 pp, $31.95(hb), ISBN 0 931250 49 8 The knee, Philippe Segal and Marcel Jacob, Wolfe Medical Publications, Frome, Somerset, 1984. 143 pp (hb), £15, ISBN 2 224 00887 2 Psychological foundations of sport, J.M. Silva and R.S. Weinberg (eds), Human Kinetics, Champaign, Illinois, (distributed in the UK by Eddington Hook & Co), 1984. xxiv + 528 pp, £22.50 (hb), ISBN 0 93 1250 59 5 Physical activity and the social sciences, W. Neil Widmeyer, Mouvement Publications Inc., Ithaca, 1983. 472 pp, £9.00 (pb), ISBN 0 932392 13 X 相似文献
10.
Abstract The purpose of this study was to investigate the acute effect of cigarette smoking on cardiac autonomic function in young adult smokers during dynamic exercise. Fourteen healthy young smokers (21.4 ± 3.4 years) performed peak and submaximal exercise protocols under control and smoking conditions. Resting and submaximal beat-to-beat R-R series were recorded and spectrally decomposed using the fast Fourier transformation. Smoking resulted in a significant decrease in work time, [Vdot]O2peak and peak O2 pulse (P < 0.05). Heart rate increased at rest and during submaximal exercise after smoking (P < 0.05). The raw high frequency and low frequency power were significantly reduced by smoking, both at rest and during exercise (P < 0.05). The low to high frequency ratio was higher after smoking (P < 0.05). The normalised low frequency power was also significantly increased by smoking, but only at rest (P < 0.05). These data demonstrate that the tachycardic effect elicited by smoking is accompanied by acute changes in heart rate spectral components both at rest and during exercise. Therefore, the cardiac autonomic control is altered by smoking not only at rest, but also during exercise, resulting in reduced vagal modulation and increased sympathetic dominance. 相似文献