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M. B. Cooper D. A. Jones R. H. T. Edwards C. Corbucci G. Montanari C. Trevisani 《Journal of sports sciences》2013,31(2):79-87
Carnitine is an essential co‐factor in the catabolism of fats as an energy source. The primary purpose of this study was to investigate the effect of running a marathon on the metabolism of carnitine by endurance‐trained athletes, and to evaluate the effect of carnitine administration on the performance of such exercise. The effects of marathon running on mitochondrial enzymes and cellular anti‐oxidants were also examined to assess whether the expression of these activities is altered by exercise. Subjects were 10 experienced male marathon runners aged between 19 and 25 years. Running a marathon caused a fall in the plasma content of unesterified carnitine (37%) and an increase in the level of acetylcarnitine present (288%). Loading of the athletes with L‐carnitine for 10 days before running a marathon abolished the exercise‐induced fall in plasma‐free carnitine (P<0.05) whilst amplifying the production of acetylcarnitine (P<0.05). Carnitine loading of the athletes studied made no detectable improvement in performance of the marathon (P > 0.05). Cytochrome oxidase, succinate cytochrome C reductase and Superoxide dismutase activities present in skeletal muscle were unaltered by marathon running. However, such exercise caused a large increase in the tissue content of oxidized glutathione (189%) at the expense of reduced glutathione (–18%). 相似文献
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Wu Tian-xing Song Zeng-fu Cai Li-sheng Ding Xue-yan Yu Qing-sen 《Journal of Zhejiang University. Science. B》2005,6(8):798-802
Effects of dietary supplementation with fructooligosaccharides on the excretion of nitrogen and phosphorus inMiichthys miiuy fries were investigated. Nine hundredMiichthys miiuy fries were divided into 3 groups, each with triplicates. The basal diet and the basal diet supplemented with carnitine groups
were considered as the negative and positive controls respectively. Results showed that the nitrogen concentration in excreted
feces decreased significantly in fries fed the diet supplementation with 1000×10−6 fructooligosaccharides and 200×10−6 carnitine (P<0.05). The ammonic-nitrogen concentration decreased significantly in the carnitine group only (P<0.05), indicating the decreasing tendency caused by the supplementation with fructooligosaccharides. Supplementation with
both did not have significant effects on the concentration of phosphorus in feces ofMiichthys miiuy fries.
Project supported by Public Bidding Item in Key Research of Zhejiang Province (No. 02110281-2) and Ningbo Tackle Key Problem
for Agricultural Development (No. 2004C-100030), China 相似文献
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L-carnitine is popular as a potential ergogenic aid because of its role in the conversion of fat into energy. The present study was undertaken to investigate the effect of short term supplementation of L-carnitine on metabolic markers and physical efficiency tests under short term calorie restriction. Male albino rats were divided into four groups (n = 12 in each)—control, calorie restricted (CR for 5 days, 25 % of basal food intake), L-carnitine supplemented (CAR, given orally for 5 days at a dose of 100 mg/kg), CR with L-carnitine supplementation (CR + CAR). Food intake and body weight of the rats were measured along with biochemical variables like blood glucose, tissue glycogen, plasma and muscle protein and enzymatic activities of CPT-1 (carnitine palmitoyl transferase-1) and AMP kinase. Results demonstrated that L-carnitine caused marked increase in muscle glycogen, plasma protein, CPT-1 activity and swim time of rats (P < 0.05) on short term supplementation. In addition to the substantive effects caused by CR alone, L-carnitine under CR significantly affected muscle glycogen, plasma protein, CPT-1 activity and AMP kinase (P < 0.05). Short term CR along with L-carnitine also resulted in increased swim time of rats than control, CR and L-carnitine treated rats (P < 0.05). The present study was an attempt towards developing an approach for better adherence to dietary restriction regimen, with the use of L-carnitine. 相似文献
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D. K. Srivastava S. Kumar A. P. Misra 《Indian journal of clinical biochemistry : IJCB》1992,7(1):19-21
A 24 week follow-up study on lipid change following maintenance haemodialysis (MHD) in 25 chronic renal failure (CRF) patients
revealed significantly raised serum Triacylglycerol (TAG) levels in these cases (P<0.001), while cholesterol and HDL-Cholesterol
did not show any significant change, the extent of increase was 10.5±3.6% after 12 weeks and 23.0±5.8% after 24 weeks. Corresponding
increase in CRF patients treated conservatively, without haemodialysis, were 3.1±1.2% and 7.2±2.7% at these intervals. Subsequent
oral administration of L-Carnitine (5mg/kg body weight twice a day) for three weeks brought about a significant reversal of
elevated serum TAG level in MDH group as well as in the conservatively treated group (P≤0.05).
It is concluded that the haemodialysis induced Hyper-Triacylglycerolemia of CRF patients is revertible by Carnitine replenishment.
Even the concomitant increase in conservatively treated group is revertible by carnitine administration. 相似文献
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