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Basic fibroblast growth factor alleviates brain injury following global ischemia reperfusion in rabbits 总被引：9，自引：0，他引：9
Zhang M Ma YF Gan JX Jiang GY Xu SX Tao XL Hong A Li JK 《Journal of Zhejiang University. Science. B》2005,6(7):637-643
The aim of this study was to explore the protective effect of basic fibroblast growth factor (bFGF) on brain injury following global ischemia reperfusion and its mechanisms. Brain injury following global ischemia was induced by four vessels occlusion and systemic hypotension. Twenty-four rabbits were randomized into three groups: group A, only dissection of vessels; group B, intravenous infusion of normal saline after reperfusion for 6 h; group C, 30 μg/kg bFGF injected intravenously at the onset of reperfusion, then infused with 10 μg/(kg·h) for 6 h. Serum neuron specific enolase (NSE), S-100B, tumor necrosis factor-α(TNF-α), interleukin-1 (IL-1), interleukin-8 (IL-8) were measured before ischemia, 30 min after ischemia, 0.5, 1, 3, 6 h after reperfusion. Brain water content was determined and cerebral histopathological damages were compared. NSE and S-100B were increased 1 h after reperfusion and reached their peaks 6 h after reperfusion, but were much higher in group B than those in group C 3, 6 h after reperfusion. In groups B and C, TNF-a was increased after ischemia and IL-1 and IL-8 were increased significantly 0.5 h after reperfusion, then reached their peaks 6 h, 3 h, 6 h after reperfusion respectively. TNF-a and IL-8 at the time points of 1 h and 3 h and IL-1 at 3 h and 6 h in group C were correspondingly lower than those in group B. These indices in group A were nearly unchanged. There were less severe cerebral histopathological damages in group C compared with group B, but no difference in brain water content. It could be concluded that bFGF alleviates brain injury following global ischemia and reperfusion by down-regulating expression of inflammatory factors and inhibiting their activities. 相似文献
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Jing Li Xin-yue Liu Lin-jing Li Chong-ge You Lei Shi Shang-di Zhang Qian Liu Jun Wang Ze-jing Liu Ting-hong Lv 《Journal of Zhejiang University. Science. B》2015,16(7):632-639
A total of 64 patients with β-lactam allergy and 30 control subjects were enrolled in a case-control study. This study is aimed to analyze the relationship between β-lactam allergy and 10 single nucleotide polymorphisms (SNPs) in interleukin-10 (IL-10), IL-13, IL-4Rα, high-affinity immunoglobulin E-receptor β chain (FcεRIβ), interferon γ receptor 2 (IFNGR2), and CYP3A4, and within the Han Chinese population of Northwest China. Genotyping for the SNPs was conducted using the Sequenom MassARRAY®platform. SPSS 17.0 was employed to analyze the statistical data and SHEsis was used to perform the haplotype reconstruction and analyze linkage disequilibrium of SNPs of IL-10 and IL-13. The results showed that the genotype distribution of CYP3A4 rs2242480/CT differed significantly between case and control groups of males (P=0.022; odds ratio (OR)=0.167, 95% confidence interval (CI): 0.032–0.867). Further analysis showed that CCA, CCG, and TAA haplotypes of IL-10 had no significant correlation in patients with β-lactam allergy. The correlation between CCT and CAC haplotypes of IL-13 and β-lactam allergy needs to be further studied. The analysis did not reveal any differences in the distribution of others gene polymorphisms between cases and controls. 相似文献
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赵子建 《成都体育学院学报》2012,38(6):88-91
以雄性3月龄大鼠为实验对象,随机分为安静对照组(WK-R),运动前即刻宰杀组(WK-B),运动后即刻宰杀组(WK-A)和运动后3小时宰杀组(WK-3H),采用恒定负荷跑台运动方式,运动时间分为一次性运动和4周有氧耐力运动。结果:(1)一次急性运动后即刻组大鼠与安静对照组相比,WK-B组血清IL-1水平显著升高(P<0.01),而WK-3H组IL-1的水平虽有下降(P<0.05),但仍然高于WK-R组(P<0.05)。(2)4周恒定负荷有氧耐力运动,除第三周运动3小时宰杀组外,IL-1的水平在其他4周各组都呈现出"升-升-降"的趋势,在第三周有明显上升,第四周达到最高峰。 相似文献
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运动对白细胞介素-1、白细胞介素-2与白细胞介素-6影响的研究进展 总被引：7，自引：0，他引：7
赵可伟 《首都体育学院学报》2005,17(5):43-45,67
运用文献资料法论述了白细胞介素的生成、功能，综述了不同运动方式对白细胞介素-1、白细胞介素-2和白细胞介素-6的影响，以探讨白细胞介素对运动的应答性规律及白细胞介素在运动免疫中的调节作用。 相似文献
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Medha Rajappa Binita Goswami A. Balasubramanian Baidarbhi Chakraborty S. Kumar 《Indian journal of clinical biochemistry : IJCB》2015,30(3):281-285
Coronary artery disease (CAD) is a global epidemic currently. This study was planned to evaluate markers of inflammation and hemostasis and their possible association, if any, in patients with CAD. The study was carried out in 60 patients with acute myocardial infarction (AMI) and 60 age and gender matched controls. The following parameters were assayed in all study subjects-inflammatory-interleukin (IL)-10, high sensitivity C-reactive protein (hs-CRP), tumor necrosis factor (TNF)-α, fibrinogen; hemostatic-fibrinogen, fibrin D-dimer and a novel risk factor—homocysteine. Inflammatory markers (hs-CRP, TNF-α and IL-10), fibrinogen, fibrin D-dimer and homocysteine levels were significantly higher in the patients with AMI, as compared with controls. A positive correlation was observed between D-dimer and the inflammatory markers—hs-CRP and TNF-α. Upon multivariate analysis, TNF-α emerged as the best determinant of CAD in our study. Our results indicate that there is a possible interplay of inflammation and hemostasis in CAD, underlining their synergistic role in the pathogenesis of CAD. 相似文献
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