排序方式： 共有13条查询结果，搜索用时 15 毫秒
1.
Shrish Bhatnagar Farzana K. Beig Ashraf Malik 《Indian journal of clinical biochemistry : IJCB》2008,23(3):299-301
Adenosine deaminase and C-reactive protein in CSF were assessed in 72 cases of Tubercular meningitis, 24 cases of partially
treated pyogenic meningitis, 20 cases of Aseptic meningitis and 8 cases of febrile seizures. Mean Adenosine deaminase value
was 12.12±3.13 IU/L for Tubercular meningitis group. It was significantly higher (p<0.001) as compared to partially treated
pyogenic meningitis (5.39±2.70 IU/L) and aseptic meningitis (1.92±0.56 IU/L) groups. A combination of clinical criteria along
with biochemical test of Adenosine deaminase and C-reactive protein in CSF increased the sensitivity of diagnosing Tubercular
meningitis and differentiating it from other forms of meningitis at an early stage. 相似文献
2.
Yan-xia Ning Shun-lin Ren Feng-di Zhao Lian-hua Yin 《Journal of Zhejiang University. Science. B》2010,11(5):350-356
Objective:To determine the effect of steroidogenic acute regulatory protein(StAR) overexpression on the levels of adenosine triphosphate(ATP)-binding cassette transporter A1(ABCA1) and ATP-binding cassette transporter G1(ABCG1) in an endothelial cell line(bEnd.3).Methods:The StAR gene was induced in bEnd.3 cells with adenovirus infection.The infection efficiency was detected by fluorescence activated cell sorter(FACS) and fluorescence microscopy.The expressions of StAR gene and protein levels were detected ... 相似文献
3.
Adenosine diphosphate(ADP)-ribosylation is a unique post-translational modification that regulates many biological processes,such as DNA damage repair.During DNA repair,ADP-ribosylation needs to be reversed by ADP-ribosylhydrolases.A group of ADP-ribosylhydrolases have a catalytic domain,namely the macrodomain,which is conserved in evolution from prokaryotes to humans.Not all macrodomains remove ADP-ribosylation.One set of macrodomains loses enzymatic activity and only binds to ADP-ribose(ADPR).Here,we summarize the biological functions of these macrodomains in DNA damage repair and compare the structure of enzymatically active and inactive macrodomains.Moreover,small molecular inhibitors have been developed that target macrodomains to suppress DNA damage repair and tumor growth.Macrodomain proteins are also expressed in pathogens,such as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).However,these domains may not be directly involved in DNA damage repair in the hosts or pathogens.Instead,they play key roles in pathogen replication.Thus,by targeting macrodomains it may be possible to treat pathogen-induced diseases,such as coronavirus disease 2019(COVID-19). 相似文献
4.
胸水腺苷脱氨酶检测对结核性胸膜炎的诊断意义 总被引：3，自引：0，他引：3
目的：探讨胸水的腺苷脱氨酶（ADA）测定值对结核性胸膜炎的诊断意义和应用价值。方法：对436例住院的胸腔积液患者分别行结核菌素纯蛋白衍生物（PPD）试验，同时应用酶速率法检测胸水标本中ADA的活性．比较二者的灵敏度及特异度。所有患者试验前均未行抗结核治疗。结果：ADA试验灵敏度（96．1％）高于PPD（90．2％）。二者差异有显著性（P〈0．05）。结论：胸腔积液ADA含量的检测对于早期诊断及治疗结核性胸膜炎具有积极意义。 相似文献
5.
通过文献检索方法对腺苷酸活化蛋白激酶参与运动引起骨骼肌适应的基因表达调节机制进行综述.从腺苷酸活化蛋白激酶相关生物知识、运动调节腺苷酸活化蛋白激酶激活和腺苷酸活化蛋白激酶参与运动训练与基因表达的可能作用三个方面进行探讨,为运动训练提供参考. 相似文献
6.
A. Madhavi Reddy Y. N. Rao Yogendra Singh Alpana Saxena 《Indian journal of clinical biochemistry : IJCB》1995,10(2):66-71
Adenosine deaminase and protein tyrosine phosphatase activities in liver and peritoneal macrophages were estimated in control,
streptozotocin induced diabetes and insulin treated diabetic groups of Swiss albino mice. Both the enzyme levels were elevated
while glycogen content decreased in the liver of diabetic group of animals as compared to controls, while in insulin treated
group, they were comparable to control levels. In macrophages also, both adenosine deaminase which plays an important role
in their maturation and protein tyrosine phosphatase enzyme involved in their activation were high in diabetic group, whereas
in insulin treated diabetic group, the values were comparable to control levels. *** DIRECT SUPPORT *** A00FN011 00003 相似文献
7.
Shrinivas B. Rao 《Indian journal of clinical biochemistry : IJCB》2001,16(2):140-144
Endogenous adenosine formed from ADP and AMP by the action of ATPase and 5′-nucleotidase is known to cause bronchoconstriction
and asthma in humans. It has been suggested that this action of adenosine is due to its binding to specific purino receptors
in the mast cells in the lungs and consequent release of mediators which elicit bronchoconstriction and asthma. The release
of these mediators leading to asthma was also believed to be due to vagal stimulation by adenosine. Though the role of adenosine
in causing bronchoconstriction leading to asthma is well confirmed the actual mode of action and details of the mechanisms
involved in the clinical manifestation of asthma remain unclear. 相似文献
8.
Meena Verma Sanjeev Narang Ashish Moonat Akshra Verma 《Indian journal of clinical biochemistry : IJCB》2004,19(1):129-131
Tuberculosis has, in a short span of time, become a major health problem in the third world or developing countries like India.
In view of this, a retrospective study was conducted to study Adenosine deaminase activity in serum and pleural fluid in patients
affected with Pulmonary Tuberculosis and other common non-tubercular chronic respiratory diseases. The study was carried out
on 100 patients suffering from various pulmonary disorders, between January 2002 and August 2002. Thirty-five normal healthy
individuals were included as control subjects. ADA estimation was done by sensitive colorimetric method. The study revealed
that the serum ADA activity was higher in patients of tuberculous pulmonary and pleural diseases and non-tuberculous pulmonary
diseases than in control subjects. The mean serum ADA activity in the patients’ group was 35.5±6.93 u/l as compared to 16.20±2.85
u/l in control group, showing a highly significant (P≪0.001) difference. ADA activity was highest in tuberculous pleuropulmonary
diseases. The pleural fluid ADA activity was higher in pyogenic pleural effusion than in tuberculous pleural effusion. 相似文献
9.
Anjali C. Warrier Narasimha Y. Rao Devdutta S. Kulpati Tarun K. Mishra Bhaskar C. Kabi 《Indian journal of clinical biochemistry : IJCB》1995,10(1):9-13
There was increase in erythrocyte lipid peroxidation and adenosine deaminase (ADA) activity in red blood cells (RBC's), white
blood cells (WBC's) and plasma, in 30 patients of confirmed diabetes mellitus, 10 each of insulin dependent diabetes mellitus
(IDDM or type I), non-insulin dependent diabetes mellitus (NIDDM or type II) and diabetes with ketoacidosis when compared
with 20 healthy individuals (controls). Glycosylated hemoglobin A1c%, plasma free fatty acid (FFA) and glycerol levels were
also elevated in all the cases when compared with controls. The increase was more in diabetic ketoacidosis group. Significant
positive correlations were seen between erythrocyte lipid peroxidation and ADA activities in RBC's, WBC's and plasma. It is
suggested that decreased tissue adenosine levels due to increase in ADA activity, is related to the severity of hyperglycemia
and lipid peroxidation in diabetes mellitus. 相似文献
10.
Hui Cheng Yin-yin Dai Ru-hong Jiang Qiang Liu Ya-xun Sun Jian-wei Lin Zu-wen Zhang Shi-quan Chen Jun Zhu Xia Sheng Chen-yang Jiang 《Journal of Zhejiang University. Science. B》2014,15(10):915-922