| 生物电信号激励与探测用微电极阵列 |
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| 引用本文： | 潘海仙,吕晓迎,王志功,方涛,邱雷,黄宗浩.生物电信号激励与探测用微电极阵列[J].东南大学学报,2011(4):361-366. |
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| 作者姓名： | 潘海仙 吕晓迎 王志功 方涛 邱雷 黄宗浩 |
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| 作者单位： | 东南大学生物电子学国家重点实验室;东南大学射频与光电集成电路研究所 |
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| 基金项目： | The National Natural Science Foundation of China(No. 61076118, 90307013, 90707005);the Natural Science Foundation of Jiangsu Province (No. BK2008032);Special Foundation and Open Foundation of the State Key Laboratory of Bioelectronics of Southeast University |
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| 摘 要： | 介绍了一种微电极阵列(MEA),该MEA包含60个独立的电极,其中59个为工作电极,一个为参考电极.工作电极成对排列,每一对工作电极分别包含一个激励电极和一个探测电极.结合外围电路,每一对工作电极的组合都可以实现对电极表面培养的生物组织或切片进行4种状态(激励、探测、同时激励和探测、隔离)的控制.MEA采用PCB工艺制...
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| 关 键 词： | 微电极阵列(MEA) 激励与探测 胞外记录 蟾蜍坐骨神经 |
Microelectrode array for bioelectrical signal stimulation and recording |
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| Pan Haixian,Lü Xiaoying,Wang Zhigong,Fang Tao,Qiu Lei,Huang Zonghao.Microelectrode array for bioelectrical signal stimulation and recording[J].Journal of Southeast University(English Edition),2011(4):361-366. |
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| Authors: | Pan Haixian Lü Xiaoying Wang Zhigong Fang Tao Qiu Lei Huang Zonghao |
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| Institution: | 1 State Key Laboratory of Bioelectronics,Southeast University,Nanjing 210096,China)(2 Institute of RF-& OE-ICs,Southeast University,Nanjing 210096,China) |
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| Abstract: | A microelectrode array(MEA) is presented,which is composed of 60 independent electrodes with 59 working ones and one reference one,and they are divided into 30 pairs.Except for the reference electrode,each pair consists of one stimulating electrode and one recording electrode.Supported by the peripheral circuits,four electrode states to study the bioelectrical signal of biological tissue or slice cultured in-vitro on the surface of the electrodes can be realized through each pair of electrodes.The four electrode states are stimulation,recording,stimulation and recording simultaneously,and isolation.The state of each pair of working electrodes can be arbitrarily controlled according to actual needs.The MEAs are fabricated in printed circuit board(PCB) technology.The total area of the PCB-based MEA is 49 mm×49 mm.The impedance measurement of MEA is carried out in 0.9% sodium chloride solution at room temperature by means of 2-point measurements with an Agilent LCR meter,and the test signal for the impedance measurement is sinusoidal(AC voltage 50 mV,sweeping frequency 20 Hz to 10 kHz).The electrode impedance is between 200 and 3 kΩ while the frequency is between 500 and 1 000 Hz.The electrode impedance magnitude is inversely proportional to the frequency.Experiments of toad sciatic nerve in-vitro stimulation and recording and signal regeneration between isolated toad sciatic nerves are carried out on the PCB-based MEA.The results show that the MEA can be used for bioelectrical signal stimulation,recording,stimulation and recording simultaneously,and isolation of biological tissues or slices in-vitro. |
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| Keywords: | microelectrode array(MEA) stimulation and recording extracellular recording toad sciatic nerve |
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