| NF-κB在肝癌介入治疗后癌旁肝细胞中的表达 |
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| 引用本文： | 张靓,杜伟.NF-κB在肝癌介入治疗后癌旁肝细胞中的表达[J].大理师专学报,2014(10):42-46. |
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| 作者姓名： | 张靓 杜伟 |
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| 作者单位： | 大理学院附属医院,云南大理671000 |
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| 基金项目： | 国家自然科学基金资助项目（81241131）;云南省教育厅科学研究基金资助项目（2013J113） |
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| 摘 要： | 目的：探讨NF-кB在肝癌介入治疗后肿瘤组织和癌旁肝细胞中的表达及其变化特点。方法：建立VX2肝癌模型兔59只，分为A组（肝癌组）29只，B组（肝癌经导管肝动脉栓塞介入组）30只、C组（对照组）20只，免疫组化检测各组肝癌及癌旁肝组织中的NF-кB表达。结果：A组肝癌组织与癌旁肝组织NF-κB阳性表达率分别为72.4%（21/29）、37.9%（11/29），肝癌介入治疗后肝癌组织和癌旁组织NF-κB阳性表达率82.4%（24/30）、60%（18/30），C组NF-κB阳性表达率为10%（2/20），各组与对照比较，除A组癌旁肝组织外差异均有统计学意义（P〈0.05），其余两两比较差异无统计学意义（P〉0.05）。结论：治疗前癌旁组织，其内NF-кB的表达水平尚处于较低水平，介入治疗后的癌旁肝组织的脂肪变性及炎性反应等因素可能会导致NF-κB的表达增加。
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| 关 键 词： | NF-кB 肝癌 介入治疗 |
NF-кB Expression in Liver Carcinoma Tissues and Tissues Adjacent to Liver Cancer Tissues Post TACE |
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| ZHANG Liang,DU Wei.NF-кB Expression in Liver Carcinoma Tissues and Tissues Adjacent to Liver Cancer Tissues Post TACE[J].Journal of Dali Teachers College,2014(10):42-46. |
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| Authors: | ZHANG Liang DU Wei |
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| Institution: | (Affiliated Hospital of Dali University, Dali, Yunnan 671000, China) |
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| Abstract: | Objective： To explore the expression of NF-кB in Liver carcinoma tissues and adjacent noncancerous liver tissue post interventional therapy and its characteristic changes. Methods： 59 rabbits with VX2 carcinoma model were randomly divided into 2 groups, 29 in group A （liver cancer）, and 30 in group B （ liver cancer/transcatheter hepatic arterial embolization, TACE） as a study group. And in group C 20 rabbits with no liver cancer as a control group. Immunohistochemical detection of NF-кB in liver cancer tissue and normal tissues adjacent to liver cancer tissue was done. Results：In group A, positive expression rate of NF-κB was 72.4%（21/29） in cancerous liver tissue and 37.9 %（ 11/29） in liver tissue adjacent to carcinoma. In group B （post interventional therapy） positive expression rate of NF-κB was 82.4%（24/30） in liver cancer tissues and 60%（18/30） in adjacent tissues. In group C, NF-κB positive expression rate was 10%（2/20）. Then each group was compared with control. Except in liver tissue adjacent to carcinoma in group A, the data recorded was statistically significant （P 〈 0.05）. The other two data had no statistical significance （P 〉 0.05）. Conclusion： The expression level of NF-κB is relatively low before interventional therapy in the tissue adjacent to carcinoma. Post interventional therapy. There is increased expression of NF-κB, may be due to the fatty degeneration of liver tissues adjacent to carcinoma and inflammatory reaction. |
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| Keywords: | NF-кB liver carcinoma interventional therapy |
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