Effect of intraperitoneal administration of carbohydrates on simulated altitude tolerance in rats |
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| Authors: | Ratan Kumar D P Chattopadhyay Radhey Shyam |
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| Institution: | 1. Department of Biochemistry, Defence Institute of Physiology and Allied Sciences, 110010, Delhi Cantt
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| Abstract: | Intraperitoneal administration of glucose (20%), Sucrose (20%) and mannitol (15%) to the rats, at a dose of 5ml/100g body weight 3 hrs. prior to hypoxic exposure (simulated high altitude 10,973m, 32°C) significantly increased the hypoxic tolerance. Intraperitoneal administration of these solutions resulted in accumulation of transudate fluid in the peritoneal cavity. A decrease in the excretion of urine, increase in hematocrit value, haemoglobin level, blood viscosity and serum protein were observed. Moisture content of lungs amongst other tissue was found to be decreased. Results are suggestive that dialysis across the peritoneal membrane might have removed some material from the blood in the peritoneal fluid which might have been responsible for the increased hypoxic tolerance. |
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