| 血管内皮生长因子在输卵管妊娠母胎界面的表达 |
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| 引用本文： | 季银芬,石一复,陈利友,周彩云.血管内皮生长因子在输卵管妊娠母胎界面的表达[J].科技通报,2007,23(1):63-66. |
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| 作者姓名： | 季银芬 石一复 陈利友 周彩云 |
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| 作者单位： | 浙江大学,医学院附属妇产科医院,杭州,310006 |
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| 摘 要： | 目的 研究血管内皮生长因子(VEGF)在输卵管妊娠的种植部位、非种植部位及分泌中期正常壶腹部输卵管的表达.方法 收集输卵管妊娠的种植部位、非种植部位标本各30例,以及分泌中期正常壶腹部输卵管标本17例.采用电化学发光法检测术前血β-HCG及免疫组织化学二步法测定各组标本中VEGF的表达,根据阳性率和表达强度进行组织化学评分和相关性分析.结果 (1)种植部位输卵管粘膜上皮细胞VEGF的表达显著高于非种植部位,差异有统计学意义(P＜0.05);(2)种植部位输卵管粘膜上皮细胞VEGF的表达显著高于正常分泌期组,差异有统计学意义(P＜0.05);(3)非种植部位组与正常分泌期组之间VEGF表达差异无统计学意义(P＜0.05);(4)输卵管妊娠活胎病例中种植部位、非种植部位的VEGF表达均与血β-HCG呈统计学正相关(均P＜0.05).结论 VEGF可能参与输卵管妊娠时胚泡植入和胎盘血管网形成.
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| 关 键 词： | 异位妊娠 输卵管 血管内皮生长因子 免疫组织化学 |
| 文章编号： | 1001-7119（2007）01-0063-04 |
| 收稿时间： | 2006-02-07 |
| 修稿时间： | 2006年2月7日 |
Expression of Vascular Endothelial Growth Factor in Maternal-fetal Interface in Tubal Ectopic Pregnancy |
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| JI Yin-fen,SHI Yi-fu,CHEN Li-you,ZHOU Cai-yun.Expression of Vascular Endothelial Growth Factor in Maternal-fetal Interface in Tubal Ectopic Pregnancy[J].Bulletin of Science and Technology,2007,23(1):63-66. |
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| Authors: | JI Yin-fen SHI Yi-fu CHEN Li-you ZHOU Cai-yun |
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| Abstract: | Objective To compare the expression of vascular endothelial growth factor(VEGF) in the implantation and nonimplantation sites of the human oviduct with ectopic pregnancy and ampullary regions of normal oviduct during mid-secretory phase.Methods Thirty patients who were undergone salpingectomy for tubal pregnancy were enrolled;all the oviduct tissues were isolated from the implantation and nonimplantation sites.At the same time seventeen normal ampullary oviducts during mid-secretory phase were included as control group.The routine two-step immunohistochemical technique was performed.Results The expression of VEGF in implantation site of the human oviduct with ectopic gestation was significantly higher than those in the nonimplantation site(P<0.05)and normal ampullary oviducts during mid-secretory phase(P<0.05).There was no significant difference between the nonimplantation site and normal ampullary oviducts during mid-secretory phase(P>0.05).Conclusion The results suggest that VEGF may be the angiogenic factor responsible for the implantation and placentation of an ectopic pregnancy in the oviduct. |
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| Keywords: | ectopic pregnancy oviduct VEGF immunohistochemistry |
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