Effect of simultaneous sodium oxalate and methionine feeding with and without Varuna (Crataeva nurvala hook & Frost) therapy on urolithogenesis in guinea pigs |
| |
| Authors: | P P Singh F Hussain Reeta Ghosh A Ahmed R C Gupta |
| |
| Institution: | 1. Department of Biochemistry, R.N.T. Medical College, 313 001, Udaipur (Rajasthan), India
|
| |
| Abstract: | The effect of sodium oxalate and methionine supplementation on stone-related constituents of urine was studied in 18 adult
male guinea pigs. Their serum and tissue chemistry and histological changes in urinary tract and liver were also studied.
The calciuretic effect of methionine was blocked by oxalate. The decrease in uric acid and citric acid, caused by oxalate,
was offset by methionine. Oxalate-induced crystalluria and calcium and oxalate deposition in kidney tissue were lessened by
methionine.
Administration of Varuna, an indigenuous drug, to oxalate and methionine-supplemented animals prevented either totally or
partially most of the urolithogenic effects of oxalate and methionine. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
