| 有氧运动上调饮食性高脂血症大鼠肝脏LCAT mRNA 的表达 |
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| 引用本文： | 张 娜,赵 斐,张 勇.有氧运动上调饮食性高脂血症大鼠肝脏LCAT mRNA 的表达[J].天津体育学院学报,2000,15(4):15-17. |
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| 作者姓名： | 张 娜 赵 斐 张 勇 |
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| 作者单位： | [1]天津体育学院研究生部，天津300381 [2]天津体育学院运动医学研究所，300381 |
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| 基金项目： | 天津市自然科学基金项目 !(0 0 360 62 1 1 ) |
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| 摘 要： | 胆固醇的逆向转运(RCT)在防止动脉粥样硬化(AS)的发生和发展中起重要作用，卵磷脂胆固醇酯酰转移酶(LCAT)是此过程的关键酶。该研究通过建立高脂高胆固醇膳食诱导SD大鼠高脂血症的实验动物模型和有氧运动训练模型，用RT-PCR方法测定高脂膳食和有氧运动对肝脏LCAT mRNA表达的影响。结果提示：高脂膳食在转录水平有下调肝脏LCAT表达的作用，而有氧运动可以有效地对抗此作用；限制饮食和运动干预对高脂血症也有一定的改善作用，使肝脏LCAT mRNA表达量增加。
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| 关 键 词： | LCAT mRNA 高脂血症 有氧运动 |
AEROBIC TRAINING UP-REGULATED THE HEPATIC EXPRESSION
OF LCAT mRNA IN DIET-INDUCED HYPERLIPIDEMIC RATS |
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| ZHANG N,ZHAO Fei and ZHANG Yong.AEROBIC TRAINING UP-REGULATED THE HEPATIC EXPRESSION
OF LCAT mRNA IN DIET-INDUCED HYPERLIPIDEMIC RATS[J].Journal of Tianjin Institute of Physical Education,2000,15(4):15-17. |
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| Authors: | ZHANG N ZHAO Fei and ZHANG Yong |
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| Institution: | ZHANG Na 1,ZHAO Fei 2,ZHANG Yong 2 |
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| Abstract: | Reverse cholesterol transport(RCT) plays an important role in preventing atheriosclerosis(AS). Lecithin cholesterol acyltransferase(LCAT) is a key enzyme involved in this process. RT PCR was used to observe the effect of high fat cholesterol(HFC) diet and aerobic exercise on expression of hepatic LCAT mRNA. It suggests that HFC diet can down regulate the expression while aerobic exercise can antagonize the influence effectively; Diet intervention and swimming training can also in some extent ameliorate the lipid metabolic disorder, which make an increase in hepatic LCAT mRNA expression. |
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| Keywords: | LCAT mRNA hyperlipidemia aerobic training |
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