3D printed microfluidic devices with integrated valves |
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| Authors: | Chad I Rogers Kamran Qaderi Adam T Woolley Gregory P Nordin |
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| Institution: | 1Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah 84602, USA;2Department of Electrical and Computer Engineering, Brigham Young University, Provo, Utah 84602, USA |
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| Abstract: | We report the successful fabrication and testing of 3D printed microfluidic devices with integrated membrane-based valves. Fabrication is performed with a low-cost commercially available stereolithographic 3D printer. Horizontal microfluidic channels with designed rectangular cross sectional dimensions as small as 350 μm wide and 250 μm tall are printed with 100% yield, as are cylindrical vertical microfluidic channels with 350 μm designed (210 μm actual) diameters. Based on our previous work Rogers et al., Anal. Chem. 83, 6418 (2011)], we use a custom resin formulation tailored for low non-specific protein adsorption. Valves are fabricated with a membrane consisting of a single build layer. The fluid pressure required to open a closed valve is the same as the control pressure holding the valve closed. 3D printed valves are successfully demonstrated for up to 800 actuations. |
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