| “脑舒合剂”对大鼠过度运动后大脑单胺类神经递质的影响 |
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| 引用本文： | 袁琼嘉,熊若虹,苏全生,李雪.“脑舒合剂”对大鼠过度运动后大脑单胺类神经递质的影响[J].武汉体育学院学报,2009,43(12):46. |
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| 作者姓名： | 袁琼嘉 熊若虹 苏全生 李雪 |
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| 作者单位： | 成都体育学院运动医学系,四川,成都,610041 |
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| 基金项目： | 国家自然科学基金面上项目资助 |
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| 摘 要： | 目的:观察"脑舒合剂"对大鼠过度运动后大脑单胺类神经递质的影响.为中药制剂消除运动性中枢疲劳提供实验依据.方法:将雄性SD大鼠40只(体重230±20克),随机分为:空白对照组(C组)、负重游泳组(O组)、负重游泳加低剂量组(低药组n=10,生药10g/kg)和负重游泳加高剂量组(高药组n=10,生药30g/kg).每天C组和0组灌等量蒸馏水,低药组和高药组灌服"脑舒合剂".除C组外,其余三个组递增负荷游泳至第八周.结果:经过8周大负荷游泳后,O组大鼠大脑皮质的去甲肾上腺素(NE)阳性表达水平显著性降低,低药组和高药组无显著性变化;O组大鼠大脑皮质的五羟色胺(5一HT)阳性表达水平显著性升高,低药组和高药组无显著性变化.结论:"脑舒合剂"有助于维持大脑皮质的NE水平,抑制5-HT水平升高,使大脑皮质的兴奋与抑制过程处于相对平衡状态,对过度运动后的大脑功能有良性作用.
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| 关 键 词： | "脑舒合剂" 过度运动 单胺类神经递质 大脑 |
Effects of Naoshu mixture on rats’cerebrum monoamine neurotransmitter after overtraining |
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| Abstract: | Objective: This research was designed to observe the effects of Naoshu mixture on rats’ cerebral monoamine neurotransmitter after they had overtraining. Methods: 40 male SD rats( weight 230 ±20g) were divided randomly into 4 groups: control group(group C, n =10) | burdened swimming group(group O , n =10) | burdened swimming and low dose group(low dose group , n =10 ,crude drug 10g/ kg) | burdened swimming and high dose group(high dose group , n =10 , crude drug 30g/ kg). Equivalent distilled water was given to group C and group O everyday. All the groups were given increase load swimming for eight weeks , except group C. Results: The protein expression of NE in rats’cerebral cortex was reduced significantly after overtraining in group O( p < 0. 05). But the expression of NE had no significant changes in Naoshu mixture groups. The expression of 5 - H in rats’ cerebral cortex had significant increase in group O(p < 0.05) , but there was no significant change in low dose and high dose group. Conclusion: Naoshu mixture could raise the expression of NE in cerebral cortex , keep the exciting and the depressing of cerebral cortex relative balance , and maintain better function of cerebral cortex after overtraining. |
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| Keywords: | Naoshu mixture monoamine neurotransmitters overtraining cerebrum |
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