Cellular stress and redox activity proteins are involved in gastric carcinogenesis associated with <Emphasis Type="Italic">Helicobacter pylori</Emphasis> infection expressing high levels of thioredoxin-1 |
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| Authors: | " target="_blank">Yan-yan Shi Jing Zhang Ting Zhang Man Zhou Ye Wang He-jun Zhang Shi-gang Ding |
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| Institution: | 1.Research Center of Clinical Epidemiology,Peking University Third Hospital,Beijing,China;2.Department of Gastroenterology,Peking University Third Hospital,Beijing,China;3.Department of Microbiology,Peking University Health Science Center,Beijing,China;4.Department of Biomedical Engineering, College of Engineering,Peking University,Beijing,China |
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| Abstract: | Helicobacter pylori infection is related to the development of gastric diseases. Our previous studies showed that high thioredoxin-1 (Trx1) expression in H. pylori can promote gastric carcinogenesis. To explore the underlying molecular mechanisms, we performed an isobaric tags for relative and absolute quantitation (iTRAQ)-based quantitative proteomic analysis of stomach tissues from Mongolian gerbil infected with H. pylori expressing high and low Trx1. Differences in the profiles of the expressed proteins were analyzed by bioinformatics and verified using Western blot analysis. We found three candidate proteins, 14-3-3α/β, glutathione-S-transferase (GST), and heat shock protein 70 (HSP70), in high Trx1 tissues compared with low Trx1 tissues and concluded that cellular stress and redox activityrelated proteins were involved in the pathogenesis of gastric cancer associated with H. pylori Trx1. |
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