| 乳腺癌中bag-1的表达及与腋窝淋巴结转移的关系 |
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| 引用本文： | 贠军,易军,王廷,姚青,王岭,张聚良,李晓军.乳腺癌中bag-1的表达及与腋窝淋巴结转移的关系[J].少年体育训练,2006(3). |
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| 作者姓名： | 贠军 易军 王廷 姚青 王岭 张聚良 李晓军 |
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| 作者单位： | 第四军医大学西京医院血管内分泌外科 陕西西安710032 |
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| 摘 要： | 目的探讨乳腺癌组织中bag-1的表达及其与肿瘤细胞增殖和腋窝淋巴结转移的关系。方法收集100例乳腺癌,其中有腋窝淋巴结转移的58例。采用免疫组化SABC法检测bag-1的表达情况。结果bag-1在乳腺癌组织中阳性表达率为85.0%;在I、II、III期的乳腺癌中bag-1阳性表达率分别为87.5%,82.4%,88.2%,三者无明显差异(P>0.05);有腋窝淋巴结转移的乳腺癌中bag-1阳性表达率为89.6%,无腋窝淋巴结转移的乳腺癌中bag-1阳性表达率为78.6%,无明显差异(P>0.05)。结论乳腺癌中bag-1高表达,其表达与肿瘤细胞增殖和腋窝淋巴结转移无关。
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| 关 键 词： | bag-1 免疫组化 转移 乳腺癌 |
Expression of bag-1 and its correlation with axillary lymph node metastasis in breast cancer. |
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| Abstract: | Objective To investigate the expression of bag-1 gene and its correlation with axillary lymph node metastasis in breast cancer. Methods Expression of bag-1 in 100 cases of breast cancer (58 cases with axillary lymph node metastasis ) were detected by SABC immunohistochemistry. Results The positive rate of bag-1 expression in breast cancer was 85.0%. The bag-1 expression rate among pathologic grades I,II,III were 87.5%,82.4%,88.2% respectively, and no significant difference were observed (P>0.05). The positive rates of bag-1 expression between breast cancer with axillary lymph node metastasis and that without axillary lymph node metastasis were 89.6%,78.6% respectively, and no significant difference was observed (P>0.05). Conclusion There is an overexpression of bag-1 in breast cancer and the expression is not related to axillary lymph node metastasis. |
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| Keywords: | bag-1 metastasis immunohistochemistry breast cancer |
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