| 胸苷酸合成酶和雌激素受体在乳腺癌中的表达意义及相关性 |
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| 引用本文： | 黄景利,薄爱华,王新生,张晓丽,邵雪辉.胸苷酸合成酶和雌激素受体在乳腺癌中的表达意义及相关性[J].河北北方学院学报(医学版),2010,27(2):3-7. |
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| 作者姓名： | 黄景利 薄爱华 王新生 张晓丽 邵雪辉 |
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| 作者单位： | 河北北方学院,河北,张家口,075000 |
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| 摘 要： | 目的:探讨胸苷酸合成酶(TS)和雌激素受体(ER)在乳腺癌中的表达及它们的相关性.方法:采用免疫组织化学SP法检测111例乳腺癌和38例乳腺腺瘤组织中TS和ER的表达情况.结果:乳腺腺瘤的TS和ER阳性率分别为10.53%(4/38)和36.84%(14/38),差异有显著性(P<0.05);乳腺癌病人中TS和ER的阳性率分别为31.53%(35/111)和40.54%(45/111),差异无显著性(P>0.05).乳腺癌中TS和ER的表达水平与患者年龄、发生部位、组织学类型、淋巴结转移相关性不明显(P>0.05).TS和ER在乳腺腺瘤组呈正向相关(r=0.077),而在乳腺癌组呈负向相关(r=-0.016).结论:TS在乳腺癌组表达率明显高于腺瘤(P<0.0 5);ER在良、恶性乳腺肿瘤内表达率差异无显著性(P>0.05).检测TS、ER对化疗药物选择有指导意义.
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| 关 键 词： | 胸苷酸合酶 受体/雌激素 免疫组织化学 乳腺肿瘤 乳腺腺瘤 |
Expression of Thymidylate Synthase and Estrogen Receptor nd Their Relativity in Breast Cancer |
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| Abstract: | Objective:To study the expression of Thymidylate Synthase(TS)and Estrogen Receptor(ER)and their relationship.Methods:The expression of TS and ER in 111 cases with breast cancer and 38 cases with breast adenoma were examined by immunohistochemistry(S-P method).Results:The positive rates of TS and ER were 10.53%(4/38),36.84%(14/38)in adenoma group respectively;the positive rates of TS and ER were 31.53%(35/111),40.54(45/111)in cancer group respectively.The expression levels of TS and ER in cancer were uncorrelated with the age,location,histological types and also lymph node metastasis(P>0.05).TS and ER in adenoma were positive correlation(r=0.077),however,TS and ER in cancer were negative correlation(r=-0.016).Conclusion:The positive rate of TS in cancer was significantly higher than that in adenoma(P<0.05),but expression rate of ER was not significantly different in benign、malignancy tumors(P>0.05).TS and ER are detected to guide application of chemotherapeutic agent. |
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| Keywords: | Thymidylate synthase Estrogen receptors/Androgen Immunohistochemistry Breast neoplasms Breast adenoma |
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