Lipid peroxidation and antioxidant status in blood of rheumatoid arthritis patients |
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| Authors: | D Vijayakumar K Suresh S Manoharan PhD |
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| Institution: | (1) Department of Biochemistry, Faculty of Science, Annamalai University, Annamalai Nagar-608 002, Tamilnadu, India |
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| Abstract: | The main objective of the study was to assess the oxidative stress in plasma and erythrocytes of rheumatoid arthritis patients
by measuring the levels of thiobarbituric acid reactive substances (TBARS), non-enzymatic antioxidants (vitamin E, C and reduced
glutathione) and enzymatic antioxidants superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSHPx)]. This
study has been conducted on twenty-two adult female rheumatoid arthritis patients and an equal number of healthy subjects.
Elevated lipid peroxidation and multidirectional changes in the antioxidant defence system were noticed in patients with rheumatoid
arthritis. The enhanced lipid peroxidation accompanied by disturbance in antioxidant status indicates that rheumatoid arthritis
patients are more prone to free radical mediated oxidative damage. |
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| Keywords: | Rheumatoid arthritis lipid peroxidation antioxidants |
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