Choronic effects of Lamotrigine on liver function in adult male rats |
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| Authors: | M H Meshkibaf A Ebrahimi R Ghodsi A Ahmadi |
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| Institution: | (1) Department of Biochemistry, Fasa University of Medical Sciences, Fasa, Fars, Iran;(2) Department of Pathology, Fasa University of Medical Sciences, Fasa, Fars, Iran;(3) Department of Physiology, Fasa University of Medical Sciences, Fasa, Fars, Iran |
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| Abstract: | A number of newly developed antiepileptic drugs are currently in use, among them Lamotrigine (LTG) is more common. Despite
the extensive use of this drug, it has not been possible to predict the side effects especially the hepatotoxic reactions
after long-term treatment. The present study was designed to find out alterations in the activities of liver enzymes after
chronic exposure of rats to different dose of LTG. Adults male (Wistar) rats were treated orally with LTG 5 mg/kg body weight
or 25 mg/kg body wt.] for 60 days. After the experimental period, auto analyzer carried out liver function tests. The liver
histopathology was obtained after scarifying the rats. There was a significant increase in the level of ALP, AST, ALT and
bilirubin at therapeutic dose of LTG. The increase level of these enzymes and bilirubin at toxic dose were much higher and
significant. However, the total protein and albumin significantly decreased at toxic dose of LTG. Elevation of liver enzymes
and bilirubin after chronic exposure of rats to high dose of LTG reflects hepatocellular damage that may lead to hepatitis.
It is concluded that regular liver function and drug monitoring should follow the treatment with LTG. |
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| Keywords: | Antiepileptic Lamotrigine and Liver function Hepatitis |
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