Positive influence of Methotrexate-Hydroxychloroquine combination on the expression of GM-CSF receptor on neutrophils of synovial fluid in rheumatoid arthritis |
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| Authors: | Ananth N Rao Beena V Shetty D M Vasudevan |
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| Institution: | (1) Department of Biochemistry, Amrita Institute of Medical Sciences, 682 026 Kochi, Kerala;(2) Kasturba Medical College, 575 004 Mangalore |
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| Abstract: | Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) has been inducted as a mediator of inflammation in rheumatoid arthritis.
Methotrexate combination therapy forms an important component of the treatment regimen in rheumatoid arthritis. The present
study was undertaken to evaluate the influence of Methotrexate-Hydroxychloroquine (MTX-HCQ) combination and Sulfsalazine-
Hydroxychloroquine (SSZ-HCQ) combination on the expression GM-CSFR in neutrophils isolated from synovial fluids. 15 cases
of confirmed rheumatoid arthritis patients who presented at the hospital for surgical correction of joint deformities were
selected for the study. Neutrophils isolated from the synovial fluids were used as the source of the receptor for quantitation
on an enzyme immunoassay (EIA). The EIA was developed and standardized in our laboratory for quantification of the GM-CSF
R. The findings are suggestive of the fact that the administration of MTX-HCQ combination has positive influence on the expression
of the GM-CSF R on neutrophils as against SSZ-HCQ combination. The physiological basis of this increase needs further investigation. |
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| Keywords: | Methotrexate Rheumatoid arthritis GM-CSF receptor Synovial fluid |
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