| C-[L-Ser-L-Ser]催化的不对称Reformatsky反应 |
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| 引用本文： | 蒋昌盛,卢紫苏,尤田耙.C-[L-Ser-L-Ser]催化的不对称Reformatsky反应[J].北京工业职业技术学院学报,2002(1). |
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| 作者姓名： | 蒋昌盛 卢紫苏 尤田耙 |
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| 作者单位： | 中国科技大学化学系 合肥230026
(蒋昌盛)，安徽淮北工业学校 淮北23500
(卢紫苏)，中国科技大学化学系 合肥230026(尤田耙) |
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| 摘 要： | 利用液相法合成了侧链带双羟基且具有C2 对称性的环二肽C_L_Ser_L_Ser]并将其作手性配体催化不对称的Reformatsky反应。考察了反应底物结构以及反应条件等因素对反应产物e.e.值的影响。产物的e.e.值最高达 64%。提出了可能的反应机理
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| 关 键 词： | 环二肽 手性配体 不对称Reformatsky反应 |
Asymmetric Reformatsky Reaction Catalyzed by C-[L-Ser-L-Ser] |
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| Jiang Changsheng,Lu Zisu,You Tianpa.Asymmetric Reformatsky Reaction Catalyzed by C-[L-Ser-L-Ser][J].Journal of beijing vocational & technical institute of industry,2002(1). |
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| Authors: | Jiang Changsheng Lu Zisu You Tianpa |
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| Institution: | Jiang Changsheng 1 Lu Zisu 2 You Tianpa 1 |
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| Abstract: | Cyclodipeptides C-L-Ser-L-Ser] with di-hydroxy groups on its side chains which has C2 symmetry have been synthesized and applied to catalyzing asymmetric Reformatsky reaction. The effects of amount of catalyst, reaction condition and structure of substrate on product's e.e. value have been investigated. The product's best e.e. value is up to 64%. Possible catalytic mechanism is proposed based on these results. |
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| Keywords: | Cyclo-Dipeptide Chiral ligand Asymmetric Reformatsky Reaction |
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