Studies on the age dependent changes in serum adenosine deaminase activity and its changes in hepatitis |
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| Authors: | K C Vasudha A Nirmal Kumar T Venkatesh |
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| Institution: | (1) Department of Biochemistry, Bangalore Medical College, 560 002 Bangalore;(2) Department of Biochemistry & Biophysics, St. John’s Medical College, 560 034 Bangalore;(3) Department of Biochemistry, M.S. Ramaiah Medical College, 560 054 Bangalore |
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| Abstract: | Serum Adenosine deaminase (ADA) activity in normal healthy control subjects increases upto 30 years, remains steady between
31–60 years of age and shows a steep increase in the age group of 61–70 years. This was compared with serum aspartate transaminase
(AST) and alanine transaminase (ALT) activity which also showed a gradual increase upto 40 years of age and decreased thereafter.
The activities of serum ADA, AST and ALT increased in patients with hepatitis of all age groups compared to their respective
controls. The degree of increase in the activities of the above enzymes in hepatitis, decreased with age. The present study
also shows that while studying serum ADA activity in hepatitis for diagnostic purposes, the value obtained in a particular
age group should be compared with normal range of values for the respective age group only. |
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| Keywords: | Serum ADA Hepatitis Aging |
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