| 绿茶多酚类化合物抗肿瘤作用研究 |
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| 引用本文： | 曹明富,杨贤强.绿茶多酚类化合物抗肿瘤作用研究[J].科技通报,1992,8(4):204-208. |
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| 作者姓名： | 曹明富 杨贤强 |
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| 作者单位： | 杭州师范学院生物系，浙江农业大学茶学系，杭州大学生物系 310036 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | 对荷瘤小鼠喂服一定剂量(每千克体重喂40mg、80mg和120mg)的绿茶多酚后,测定其对移植性肿瘤细胞的抑制作用,结果显示:对EAC重量的抑制率分别为65.3％、51.0％和48.7％;对S180的抑制率为66.3％、68.5％和59.8％;对EAC细胞增殖数抑制率为81.4％、77.0％和50.5％.同时测得三个试验组EAC鼠的胸腺细胞增加率为248.2％、69.6％和44.6％;脾细胞增殖率为13.5％、61.5％和22.9％;对S180鼠的胸腺细胞增加率为200.7％、73.9％和138.0％;脾细胞增加率为34.4％、31.1％和20.0％.实验结果表明:茶多酚抗肿瘤作用可能是通过增强机体免疫力来抑制体内肿瘤细胞的生长.
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| 关 键 词： | 绿茶 茶多酚 免疫功能 艾氏腹水癌 |
Study on Anticarcinogenic Activity of Green Tea Polyphenols |
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| Cao Mingfu.Study on Anticarcinogenic Activity of Green Tea Polyphenols[J].Bulletin of Science and Technology,1992,8(4):204-208. |
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| Authors: | Cao Mingfu |
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| Institution: | Cao Mingfu(Department of Biology Hangzhou Teachers College)Yan Xianquiang Yu Yanyuan(Zhejiang Agricultural University) (Hangzhou University) |
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| Abstract: | The dynamic changes of cellular immune function and anticancer effect of green tea polyphenols (TP; an
extract of green tea) in the mice bearing Ehrlich ascitic carcinoma (EAC) and sarcoma 180 (S180) tumor
were investigated. After infrsing TP into the mouse's with doses of 40mg/kg, 80mg/kg and 120mg/kg daily,
The inhibition rate of EAC tumor growth about 65.3%, 51.0% and 48.7%;the inhibition rate of EAC mul-
tiplication about 81.4%, 77.0% and 50. 5%, the inhibition rate of the S180 growth about 66.3%, 68.5%
and 59.8%, respectively. Besides, it showed all tumor-bearing mice increased their immune organ (thymus
and spleen) weights and immunocyte numbers. |
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| Keywords: | green tea tea polyphenol anticancer immunologic function sarcoma 180 Ehrlich ascitic carcinoma |
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