| Science Letters:Serum protein fingerprinting coupled with artificial neural network distinguishes glioma from healthy population or brain benign tumor |
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| 作者姓名： | 刘建 郑树 余捷凯 张建民 陈喆 |
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| 作者单位： | Cancer Institute，Second Affiliated Hospital，School of Medicine，Zhejiang University，Hangzhou310009，China，Cancer Institute，Second Affiliated Hospital，School of Medicine，Zhejiang University，Hangzhou310009，China，Cancer Institute，Second Affiliated Hospital，School of Medicine，Zhejiang University，Hangzhou310009，China，Neurosurgery Department，Second Affiliated Hospital，School of Medicine，Zhejiang University，Hangzhou310009，China，Cancer Institute，Second Affiliated Hospital，School of Medicine，Zhejiang University，Hangzhou310009，China |
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| 基金项目： | Project(No.G1998051200)supportedbytheNationalBasicResearchProgram(973)ofChina |
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| 摘 要： | To screen and evaluate protein biomarkers for the detection of gliomas(Astrocytoma grade Ⅰ-Ⅳ) from healthy in-dividuals and gliomas from brain benign tumors by using surface enhanced laser desorption/ionization time of flight mass spec-trometry(SELDI-TOF-MS)coupled with an artificial neural network(ANN)algorithm.SELDI-TOF-MS protein fingerprinting ofserum from 105 brain tumor patients and healthy individuals,included 28 patients with glioma(Astrocytoma Ⅰ-Ⅳ),37 patientswith brain benign tumor,and 40 age-matched healthy individuals.Two thirds of the total samples of every compared pair as trainingset were used to set up discriminating patterns,and one third of total samples of every compared pair as test set were used tocross-validate;simultaneously,discriminate-cluster analysis derived SPSS 10.0 software was used to compare Astrocytoma gradeⅠ-Ⅱ with grade Ⅲ-Ⅳ ones.An accuracy of 95.7%,sensitivity of 88.9%,specificity of 100%,positive predictive value of 90% andnegative predictive value of 100% wer
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Science Letters:Serum protein fingerprinting coupled with artificial neural network distinguishes glioma from healthy population or brain benign tumor |
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| LIU Jian,ZHENG Shu,YU Jie-kai.Science Letters:Serum protein fingerprinting coupled with artificial neural network distinguishes glioma from healthy population or brain benign tumor[J].Journal of Zhejiang University Science,2005(1). |
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| Authors: | LIU Jian ZHENG Shu YU Jie-kai |
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| Institution: | LIU Jian~1 ZHENG Shu~1 YU Jie-kai |
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| Abstract: | |
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| Keywords: | Astrocytoma Artificial Neural Network(ANN) SELDI-TOF-MS Protein fingerprint Diagnosis |
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