| 合成生物学的医学应用研究进展 |
| |
| 引用本文： | 崔金明,王力为,常志广,臧中盛,刘陈立.合成生物学的医学应用研究进展[J].中国科学院院刊,2018,33(11):1218-1227. |
| |
| 作者姓名： | 崔金明 王力为 常志广 臧中盛 刘陈立 |
| |
| 作者单位： | 中国科学院深圳先进技术研究院 深圳 518055,中国科学院 前沿科学与教育局 北京 100864,中国科学院深圳先进技术研究院 深圳 518055,中国科学院深圳先进技术研究院 深圳 518055,中国科学院深圳先进技术研究院 深圳 518055 |
| |
| 摘 要： | 在医学应用领域,合成生物学以人工设计的基因线路改造人体自身细胞,或改造细菌、病毒等人工生命体,再使其间接作用于人体。这些经人工设计的生命体能够感知疾病特异信号或人工信号、特异性靶向异常细胞和病灶区域、表达报告分子或释放治疗药物,从而实现对人体生理状态的监测,以及对肿瘤、代谢疾病、耐药菌感染等典型疾病的诊断与治疗。文章将综述了合成生物学的医学应用领域近期的一些研究进展。
|
| 关 键 词： | 人工细胞 人工细菌 人工病毒 人工噬菌体 |
| 收稿时间： | 2018/10/28 0:00:00 |
Progress of Synthetic Biology Research in Medical Applications |
| |
| CUI Jinming,WANG Liwei,CHANG Zhiguang,ZANG Zhongsheng and LIU Chenli.Progress of Synthetic Biology Research in Medical Applications[J].Bulletin of the Chinese Academy of Sciences,2018,33(11):1218-1227. |
| |
| Authors: | CUI Jinming WANG Liwei CHANG Zhiguang ZANG Zhongsheng and LIU Chenli |
| |
| Institution: | Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China,Bureau of Frontier Sciences and Education, Chinese Academy of Sciences, Beijing 100864, China,Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China,Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China and Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China |
| |
| Abstract: | In the field of medical applications, synthetic biology researchers design genetic circuits to modify human cells, or to modify synthetic organisms such as bacteria and viruses and make them interact with the human body. These artificially designed organisms are capable of perceiving disease-specific signals or artificial signals, targeting abnormal cells and foci, expressing reporter molecules or releasing therapeutic drugs, thus enabling the monitoring of human physiological conditions and the diagnosis and treatment of typical diseases such as tumors, metabolic diseases, and drug-resistant bacteria infections. This article will comprehensively describe some recent research progress. |
| |
| Keywords: | synthetic cell synthetic bacteria synthetic virus synthetic phage |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《中国科学院院刊》浏览原始摘要信息 |
| 点击此处可从《中国科学院院刊》下载免费的PDF全文 |
|
