Enhanced bilirubin binding to different mammalian erythrocytes in the presence of magnesium ions |
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| Authors: | M K Ali M U Siddiqui S Tayyab |
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| Institution: | (1) Department of Biochemistry, J. N. Medical College, Aligarh Muslim University, 202 002 Aligarh, U.P.;(2) Interdisciplinary Biotechnology Unit, J. N. Medical College, Aligarh Muslim University, 202 002 Aligarh, U.P. |
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| Abstract: | Effect of magnesium ions on the binding of bilirubin to erythrocytes of different mammalian species, namely, human, buffalo,
goat and sheep was studied. Increase in the concentration of magnesium ions led to a gradual increase in the erythrocyte-bound
bilirubin in both human and buffalo erythrocytes whereas in sheep and goat erythrocytes, the pronounced increase was found
beyond 2.0 and 2.7 mM MgCl2 concentrations respectively. Percentage increase in erythrocyte-bound bilirubin was found highest in human erythrocytes followed
by buffalo and sheep erythrocytes and minimum in goat erythrocytes. These differences in the binding of bilirubin to different
mammalian erythrocytes can be attributed to the differential shielding effect of metal ions which involves the masking of
negatively charged phosphate of phospholipids found on the erythrocyte surface. |
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| Keywords: | Bilirubin buffalo erythrocytes goat human mammalian species magnesium ions sheep |
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