In vitro study of vitamin B6 status in cancer breast patients |
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| Authors: | Sowbhagya Lakshmi Ramani Natarajan |
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| Institution: | 1. Karnatak Medical College, Hubli, Karnataka
2. Department of Biochemistry, Kidwai Memorial Institute of Oncology, Hosur Road, Bangalore, Karnataka
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| Abstract: | There is ample evidence that vitamin status of an individual can have a profound influence on the resistance of Cancer. Pyridoxine
is one of the water soluble vitamins playing an important role in various metabolic reactions. Aspartate aminotransferase
and Alanine aminotransferase are pyridoxal phosphate requiring enzymes and their activities in erythrocytes have been used
to assess the state of vitamin B6 nutrition in man.
We report here the erythrocyte transaminase levels in controls and patients with early and advanced cancer of breast. Thein vitro study of vitamin B6 shows a marked difference in the per cent stimulation in patients as compared to the controls on addition of pyridoxal phosphate.
The difference indicates a subclinical deficiency of vitamin B6. The possibility exists that the rapid progression of the disease could be due to lack of host resistance caused by the deficiency
of vitamin B6. The possibility of an effective treatment response after enhancing the vitamin B6 status is being looked into. |
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