| Advanced primary peritoneal carcinoma： clinicopathological and prognostic factor analyses |
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| 作者姓名： | Zhang C Li XP Cui H Shen DH Wei LH |
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| 作者单位： | Gynecological Oncology Center, Peking University People＇s Hospital Beijing 100044, China |
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| 摘 要： |
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| 关 键 词： | 因素分析 腹膜瘤 治疗方法 临床分析 |
| 收稿时间： | 10 April 2008 |
Advanced primary peritoneal carcinoma: clinicopathological and prognostic factor analyses |
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| Zhang C,Li XP,Cui H,Shen DH,Wei LH.Advanced primary peritoneal carcinoma: clinicopathological and prognostic factor analyses[J].Journal of Zhejiang University Science,2008,9(6):435-440. |
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| Authors: | Zhang Chao Li Xiao-ping Cui Heng Shen Dan-hua Wei Li-hui |
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| Institution: | Gynecological Oncology Center, Peking University People's Hospital, Beijing 100044, China. |
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| Abstract: | Objective: To investigate the factors favoring a positive prognosis for advanced primary peritoneal carcinoma (PPC). Methods: Twenty-four cases meeting the criteria for PPC were analyzed retrospectively for the clinicopathologic profiles. Immunohistochemistry was used to determine the expressions of p53, Top2α, Ki-67 and Her-2/neu. Then all these clinicopathological factors and molecular markers were correlated with the prognosis. Results: There were 15 cases of primary peritoneal serous papillary carcinoma (PPSPC), 6 cases of mixed epithelial carcinoma (MEC) and 3 cases of malignant mixed Mullerian tumor (MMMT). All patients underwent cytoreductive surgery with optimal debulking achieved in 3 cases. Among those receiving first-line chemotherapy, 13 patients received the TP regimen (paclitaxel-cisplatin or carboplatin) and 7 patients received the PAC regimen (cisplatin-doxorubicin-cyclophosphamide). The median overall survival of all patients was 42 months, while the breakdown for survival time for patients with PPSPC, MMT and MEC was 44, 13 and 19 months, respectively. The expressions of p53, Top2a and Ki-67 were all demonstrated in 11 cases respectively. None showed the expression of Her-2/neu. There were significant differences in the median survival between patients with PPSPC and those with MMMT (44 months vs 13 months, P<0.05), also between patients receiving TP combination and those receiving the PAC regimen (75 months vs 28 months, P<0.05). Another significant difference in the median progression-free survival (PFS) was identified between patients with positive p53 immunostaining and those with negative p53 immunostaining (15 months vs 47 months, P<0.05), whereas age, menopausal status, residual tumor size and the other molecular factors did not significantly impact survival. Conclusion: Patients with PPC should be treated with a comprehensive management plan including appropriate cytoreductive surgery and responsive chemotherapy. Overestimating an optimal debulking surgery may not benefit survival. The pathologic subtype, chemotherapy regimen and p53 overexpression were significant prognostic factors. |
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| Keywords: | Primary peritoneal carcinoma (PPC) Cytoreductive surgery Chemotherapy Immunohistochemistry Prognosis |
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