Increase in calcium content of erythrocyte and its significance to the function of enzyme calcium activated neutral protease (CANP) activity in β- thalassemia homozygotes and heterozygotes |
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| Authors: | CH V Ramana Devi M P J S Anandaraj |
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| Institution: | 1. Institute of Genetics Hospital of Genetic Diseeases, Osmania University, Begumpet, 500 016, Hyderabad
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| Abstract: | The enhanced presence of calcium in the erythrocytes of thalassemia homozygotes along with an increase in cytosolic and membrane
bound CANP, and a decrease in membrane glycoprotein and total membrane sulfhydryl groups are statistically significant changes.In vitro loading of erythrocytes with calcium in the presence of lonophore A23187 caused similar changes pointing to the significance of calcium mediated proteolysis, especially by CANP in preparing erythrocytes
for the phagocytic event. |
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| Keywords: | thalassemia homozygotes CANP ionophore calcium |
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