| 一锅煮法合成多取代的2-吡咯烷酮 |
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| 引用本文： | 王科伟,樊月琴,孟双明,郭永术,冯锋,贾治芳.一锅煮法合成多取代的2-吡咯烷酮[J].雁北师范学院学报,2011,27(3). |
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| 作者姓名： | 王科伟 樊月琴 孟双明 郭永术 冯锋 贾治芳 |
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| 作者单位： | 山西大同大学化学与化工学院,山西大同,037009 |
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| 摘 要： | 通过简单易得的α-乙酰基环丙基酰胺与NH2OH.HCl一锅反应,高效地合成了多取代的2-吡咯烷酮,其机理涉及到一个三元环开环和分子内亲核环合反应。对它们的结构用核磁共振氢谱、核磁共振碳谱和元素分析进行了表征。
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| 关 键 词： | 2-吡咯烷酮 环丙基酰胺 环合反应 |
Efficient One-Pot Synthesis of Highly Substituted Pyrrolidin-2-ones |
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| WANG Ke-wei,FAN Yue-qin,MENG Shuang-ming,GUO Yong,FENG Feng,JIA Zhi-fang.Efficient One-Pot Synthesis of Highly Substituted Pyrrolidin-2-ones[J].Journal of Yanbei Teachers College,2011,27(3). |
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| Authors: | WANG Ke-wei FAN Yue-qin MENG Shuang-ming GUO Yong FENG Feng JIA Zhi-fang |
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| Institution: | WANG Ke-wei,FAN Yue-qin,MENG Shuang-ming,GUO Yong,FENG Feng,JIA Zhi-fang(Shcool of Chemistry and Chemical Engineering,Shanxi Datong University,Datong Shanxi,037009) |
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| Abstract: | A facile and efficient one-pot synthesis of highly substituted pyrrolidin-2-ones is developed via the NH2OH·HCl and readily available α-acetyl cyclopropyl amide,and a mechanism involving sequential ring-opening,and intramolecular nucleophilic cyclization reactions is proposed,Their structures were characterized 1H NMR,13C NMR spectra and elemental analysis. |
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| Keywords: | pyrrolidin-2-ones cyclopropyl amide cyclization reactions |
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