| 慢性重复性低氧小鼠的红细胞增多效应 |
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| 引用本文： | 孟宪法,于洪九,徐仲崎,孔彦,韩美敦,张云英,耿排力,许存和,何加强.慢性重复性低氧小鼠的红细胞增多效应[J].大连大学学报,1994(3). |
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| 作者姓名： | 孟宪法 于洪九 徐仲崎 孔彦 韩美敦 张云英 耿排力 许存和 何加强 |
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| 作者单位： | 大连大学医学院生理教研室
(孟宪法，于洪九，徐仲崎，孔彦，韩美敦)，大连大学医学院附院检验科
(张云英)，青海医学院
(耿排力，许存和)，青海医学院(何加强) |
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| 摘 要： | 小鼠暴露于低压舱(0.42atm,22h/day)连续9天。结果表明,慢性重复低氧后,小鼠的血清促红细胞生成素(EPO)浓度迅速增高,第3天达峰值,其后迅速递减,但直至低氧后第9天,EPO仍高于低氧前水平(P<0.01)。低氧期间,小鼠的红细胞比容持续递增(P<0.01),而血浆容量无明显改变。伴随红细胞生成的增加,EPO生成存在反馈性抑制现象。
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| 关 键 词： | 促红细胞生成素 红细胞生成 小鼠 低氧 |
Erythropoiesis of Mice Exposed to Chronic Intermittent Hypoxia |
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| Meng Xianfa.Erythropoiesis of Mice Exposed to Chronic Intermittent Hypoxia[J].Journal of Dalian University,1994(3). |
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| Authors: | Meng Xianfa |
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| Institution: | Meng Xianfa |
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| Abstract: | Mice were exposed to hypobaric chamber (0. 42atm,22h/day)for 9 days. The resultssuggested that chronic intermittent hypoxia caused an early inerease,reached the highest lev-el after 3 days, followed by a rapid decline (P<0. 01) ,in serum erythropoietin(EPO) con-centration which is correlated with the hematicrit increased gradually(P<0. 01). The plasmavolume was no changed. An inhibitory effect exerted in EPO production with erythropoiesisincreased. |
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| Keywords: | Erythropoietin(EPO) Erythropoiesis Mice Hypoxia |
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