Lipid peroxidation in erythrocytes of patients with type 2 diabetes mellitus |
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| Authors: | P Ashok Kumar G Rajagopal |
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| Institution: | (1) Department of Biochemistry, Rajah Muthiah Medical College, Annamalai University, 608 002 Annamalai Nagar |
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| Abstract: | Lipid peroxidation by measurement of Thiobarbituric Acid Reactive Substances (TBARS) and antioxidant status by determining
the activities of the enzymes, Catalase (Cat), Glutathione Peroxidase (GPx) and Superoxide Dismutase (SOD) and the level of
Reduced Glutathione (GSH) in the erythrocytes of patients with type 2 Diabetes Mellitus were investigated. It was observed
that the level of TBARS in the erythrocytes was increased by 50% showing a significant generation of free radicals in the
erythrocytes of these patients. The activities of both Cat and SOD were enhanced while that of GPx was not altered. The level
of GSH was also not changed. |
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| Keywords: | Glutathione Type 2 Diabetes Catalase Peroxidase Superoxide Dismutase |
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