Effect of thiazide drug compound on the testicular protein and cholesterol contents of albino rat |
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| Authors: | Hemlata Yadav P K Singh |
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| Institution: | (1) Department of Zoology, School of Life Sciences, Khandari Campus, 282002 Agra;(2) H. No-78 West Arjun Nagar, 282 001 Agra |
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| Abstract: | In this study the effect of thiazide diuretic compound on the protein and cholesterol contents in the testes of albino rats
as the experimental model. The drug thiazide was administered orally daily for 10,20 and 30 days at the dose of 100mg/kg body
weight. Total protein decrease in the testes of rats were evidenced may be due to the side effects of thiazide drug compound
which is linked with the hyponatremia and protein metabolism. An elevated level of cholesterol contents observed in thiazide
treated rats also revealed that the side effect of drug compound thiazide and also may be due to the stimulation of catecholamine
which is stimulated therefore, the biochemical estimation such as protein and cholesterol in the testes after the thiazide
treatment determined the effectiveness of diuretic drug compound would provide clinical evidences of their side effects. |
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| Keywords: | Drug thiazide Rattus norvegicus protein cholesterol |
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