Effect of type II collagen treatment on the antioxidant status in immune tissues of adjuvant induced arthritic rats |
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| Authors: | Nalini Ganesan Hariprasad Chegu A N Chandrasekaran |
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| Institution: | (1) Dept. of Biochemistry, SRMC & RI (DU), Porur, 600 116 Chennai;(2) Govt. General Hospital, Chennai Medical College, 600 003 Chennai |
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| Abstract: | Adjuvant induced arthritis (AIA) is a model widely used to study Rheumatoid arthritis (RA). In the present study, lipid peroxides
level in spleen and thymus of AIA rats was observed to be significantly high compared to normal rats. A significant decrease
in ascorbic acid (ASA), reduced glutathione (GSH), superoxide dismutase activity (SOD) was also observed in spleen and thymus
of AIA rats compared to normal rats. There was also a steady increase in the circulating immune complex level (CIC) throughout
the experimental period in serum of AIA rats. In the present investigation, it was decided to study the effect of pre and
post treatment with TYPE II collagen on the antioxidant status and the circulating immune complex level in AIA rats. The results
from the present work indicates that the pretreatment with TYPE II collagen was effective in bringing significant changes
on all the parameters studied in AIA rats. The post treatment with TYPE II collagen was effective in bringing significant
changes on the CIC immune complex level and GSH content in the thymus tissue of AIA rats. The present work suggests that the
pre treatment with TYPE II collagen was more effective in suppressing the disease than the post treatment. |
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| Keywords: | Adjuvant arthritis antioxidants type II collagen tolerance |
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