| 脑梗塞患者血中一氧化氮对血小板功能的影响 |
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| 引用本文： | 于增国,宋光,王燕.脑梗塞患者血中一氧化氮对血小板功能的影响[J].大连大学学报,2003,24(2):74-76. |
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| 作者姓名： | 于增国 宋光 王燕 |
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| 作者单位： | 1. 大连大学,医学院,辽宁,大连,116622
2. 大连大学,医学院附属医院,辽宁,大连,116021 |
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| 摘 要： | 目的]研究脑梗塞患者血中一氧化氮(NO)的含量与血小板功能之间的关系.方法]将20例脑梗塞患者分别于发病急性期和稳定期采用硝酸还原酶法测血中NO含量;用光电比浊法和免疫荧光分析法分别测定血小板聚集率(PAgT)和血小板α-颗粒膜蛋白(GMP-140)水平;同时检测正常对照15例结果]血清中NO含量在发病急性期较正常对照明显增高(P<0.01).同时,PAgT与正常对照有显著性差异(PADP<0.05,PADR<0.01);而血小板GMP-140在急性期和稳定期较正常对照均有显著性差异(P<0.01).结论]脑梗塞发病急性期随着血中NO含量的增高,导致PAgT受抑,血小板GMP-140水平减低.
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| 关 键 词： | 脑梗塞 一氧化氮 血小板功能 |
| 文章编号： | 1008-2395(2003)02-0074-04 |
| 修稿时间： | 2003年2月28日 |
The effect of nitric oxide in serum on platelet function in patients with cerebral infarction |
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| YU Zeng-guo,SONG Guang,WANG Yan.The effect of nitric oxide in serum on platelet function in patients with cerebral infarction[J].Journal of Dalian University,2003,24(2):74-76. |
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| Authors: | YU Zeng-guo SONG Guang WANG Yan |
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| Abstract: | Objective] To study the effect of the nitric oxide (NO) in serum of patients with cerebral infarction on platelet function. Methods] Subjects were surveyed intraperitoneally in cerebral infarction exacerbation stage and cerebral infarction remission stage, and normal control group was involued in the research too. Nitric oxide, Platelet aggregation rate (PAgT) and GMP-140 were measure with reagent box, turbidimetry and immunofluorescence technique. Results] The value of NO in cerebral infarction exacerbation is increased more markedly than that of normal control group (P<0.01), and the value of PAgT is reduced significantly (PADP<0.05, PADR<0.01). The two values of GMP-140 are lower than that of normal control group (P<0.01). Conclusion] The increasing of NO level in plasma of patients with cerebral infarction restrains the platelet aggregation function and effects on platelet release function. |
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| Keywords: | cerebral infarction nitric oxide platelet function |
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