Growth factors induce the improved cardiac remodeling in autologous mesenchymal stem cell-implanted failing rat hearts |
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| Authors: | Ze-wei Tao Long-gui Li Zhao-hua Geng Tao Dang Shan-jun Zhu |
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| Institution: | (1) The Division of Cardiology, and The Interdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, Miami, FL; |
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| Abstract: | Therapeutically delivered mesenchymal stem cells (MSCs) improve ventricular remodeling. However,the mechanism underlying MSC cardiac remodeling has not been clearly determined. Congestive heart failure (CHF) was induced in rats by cauterization of the left ventricular free wall. MSCs were cultured from autologous bone marrow and injected into the border zone and the remote myocardium 5 d after injury. Ten weeks later,when compared with sham operation,CHF significantly increased nucleus mitotic index,capilla... |
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| Keywords: | Mesenchymal stem cells Growth factor Myocardium Cardiac remodeling |
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