Changes in the level of biogenic amines in cerebrospinal fluid of suicidal attempt cases |
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| Authors: | K Husain R N Sahu R Rahman A Nair |
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| Institution: | 1. Division of Pharmacology and Toxicology, Defence Research and Development Establishment, 474002, Gwalior
3. Department of Medicine, G.R. Medical College, Gwalior
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| Abstract: | The levels of norepinephrine (NE), dopamine (DA) serotonin (5-HT) and its metabolite 5-hydroxyindole acetic acid (5-HIAA)
have been determined in the cerebrospinal fluid (CSF) of normal (n=25) and suicidal attempt cases (n=30). A significant decrease
in the level of NE (p<0.01), 5-HT(p<0.001) and 5-HIAA (p<0.001) in the CSF of suicide attempt cases were observed as compared
to normal controls. It is concluded that CSF 5-HIAA level which is drastically depleted may be used as an early biochemical
indicator of suicidal attempt so that it may be treated by the drugs which can enhance the suppressed neurotransmitter activity. |
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| Keywords: | Suicide Norepinephrine Dopamine Serotonin 5-HIAA |
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