Effect of immobilisation stress on lipid peroxidation and lipid profile in rabbits |
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| Authors: | Hem Lata G K Ahuja A P S Narang Lily Walia |
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| Institution: | (1) Department of Biochemistry, Dayanand Medical College and Hospital, 141001 Ludhiana, Punjab;(2) Department of physiology, Dayanand Medical College and Hospital, 141001 Ludhiana, India |
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| Abstract: | Stress is one of the basic factors in the aetiology of a number of diseases such as atherosclerosis, coronary heart disease,
aging, liver disease etc. Hence this work was designed to study the effect of stress in the form of forced immobilisation
stress on lipid peroxidation and lipid profile in rabbits. The study was conducted in 25 healthy rabbits of either sex. Rabbits
were subjected to forced immobilisation for two hours everyday for consecutive seven days. Blood samples were collected on
day 1, 3 and 7 after immobilisation period. Malondialdehyde (MDA), a marker of lipid peroxidation was estimated by TBA assay
method. Lipid profile was analysed by multichannel autoanalyser. There was statistically significant increase in MDA, total
cholesterol, LDL, VLDL and triglycerides with immobilisation. These findings indicate that stress in the form of forced immobilisation
increases lipid peroxidation and alter lipid profile, which may be responsible for pathophysiology of various diseases. |
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| Keywords: | Immobilisation stress Lipid peroxidation Lipid profile Rabbits |
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