| 神经干细胞分化相关的一个新基因的研究 |
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| 引用本文： | 庞淑亚,赵翠萍,文铁桥.神经干细胞分化相关的一个新基因的研究[J].上海大学学报(英文版),2006,10(5):465-468. |
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| 作者姓名： | 庞淑亚 赵翠萍 文铁桥 |
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| 作者单位： | Laboratory of Neural Molecular Biology School of Life Sciences Shanghai University Shanghai 200444 P.R. China，Laboratory of Neural Molecular Biology School of Life Sciences Shanghai University Shanghai 200444 P.R. China，Laboratory of Neural Molecular Biology School of Life Sciences Shanghai University Shanghai 200444 P.R. China |
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| 基金项目： | 国家重点基础研究发展计划(973计划);国家自然科学基金 |
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| 摘 要： | 1IntroductionNeural stemcells(NSCs)are a subtype of progenitorcells in the nervous systemthat can differentiate intoneurons and glia1-3].Due to their feature of self-re-newal,NSCs have expectations for treatment of ner-vous system diseases such as Parkin…
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| 关 键 词： | 神经干细胞 鉴别 蛋白质 基因表达 |
| 文章编号： | 1007-6417（2006）05-0465-04 |
| 收稿时间： | 2005-03-29 |
| 修稿时间： | 2005-05-17 |
Insight of a novel functional gene related to differentiation of neural stem cells |
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| Shu-ya Pang,Cui-ping Zhao,Tie-qiao Wen Ph. D..Insight of a novel functional gene related to differentiation of neural stem cells[J].Journal of Shanghai University(English Edition),2006,10(5):465-468. |
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| Authors: | Shu-ya Pang Cui-ping Zhao Tie-qiao Wen Ph D |
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| Abstract: | A novel functional gene P12 was isolated from neural stem cells cultured in differentiation medium. The fully length cDNA of P12 gene was cloned and sequenced. Result showed that it contains an open reading frame encoding a protein of 291 amino acids. Further, this gene was transferred into neural stem cell. Functional analysis suggests that the expression of p12 protein is closely correlated with differentiation of neural dendrite configuration. In addition, to obtain encoding protein, P12 sequence was also expressed in Pichia pastoris yeast. |
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| Keywords: | neural stem cells differentiation protein expression Pichia pastoris |
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