Sin1-mediated mTOR signaling in cell growth,metabolism and immune response |
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| Authors: | Chun Ruan Xinxing Ouyang Hongzhi Liu Song Li Jingsi Jin Weiyi Tang Yu Xia Bing Su |
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| Institution: | 1. Shanghai Institute of Immunology, Department of Immunology and Microbiology, and the Minister of Education Key Laboratory of Cell Death and Differentiation, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China;2. Zhiyuan College, Shanghai Jiao Tong University, Shanghai 200240, China |
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| Abstract: | The mammalian target of rapamycin (mTOR) is an evolutionarily conserved Ser/Thr protein kinase with essential cellular function via processing various extracellular and intracellular inputs. Two distinct multi-protein mTOR complexes (mTORC), mTORC1 and mTORC2, have been identified and well characterized in eukaryotic cells from yeast to human. Sin1, which stands for Sty1/Spc1-interacting protein1, also known as mitogen-activated protein kinase (MAPK) associated protein (MAPKAP)1, is an evolutionarily conserved adaptor protein. Mammalian Sin1 interacts with many cellular proteins, but it has been widely studied as an essential component of mTORC2, and it is crucial not only for the assembly of mTORC2 but also for the regulation of its substrate specificity. In this review, we summarize our current knowledge of the structure and functions of Sin1, focusing specifically on its protein interaction network and its roles in the mTOR pathway that could account for various cellular functions of mTOR in growth, metabolism, immunity and cancer. |
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| Keywords: | Sin1 AGC kinases mTOR complex Akt metabolism and immune response |
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