| 消化系恶性肿瘤浸润淋巴细胞免疫组化研究 |
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| 引用本文： | 及和照,孙黎,刘春霞,刘芳,刘士先,梁晚平.消化系恶性肿瘤浸润淋巴细胞免疫组化研究[J].河北北方学院学报(医学版),1998(1). |
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| 作者姓名： | 及和照 孙黎 刘春霞 刘芳 刘士先 梁晚平 |
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| 作者单位： | 张家口医学院微生物教研室 075029
(及和照，孙黎，刘春霞，刘芳，刘士先)，张家口医学院一附院外科 075029(梁晚平) |
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| 摘 要： | 应用免疫组织化学PAP法及多种单克隆抗体,对12例常见消化系统恶性肿瘤进行了原位研究。结果显示:①TIL在肿瘤局部主要分布于癌间质区,而癌实质区仅有极少数TIL浸润;②TIL中的主导细胞为CD_3~ T细胞,且无论在实质区还是在间质区CD_4~ 细胞均少于CD_8~ ,癌间质区CD_4~ /CD_8~ 比值大于癌实质区;③无论在癌实质区还是在癌间质区,均有部分CD_(25)~ 或HLA-DR~ TIL存在,对于这些变化的内在机制文中也作了探讨。
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| 关 键 词： | 消化道 肿瘤浸润淋巴细胞 免疫组织化学 |
IMMUMOHISTOCHEMICAL STUDY ON TIL IN PATIENTS WITH CANCER OF DIGESTIVE TRACT IN SITU. |
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| Ji Hezhao et al.IMMUMOHISTOCHEMICAL STUDY ON TIL IN PATIENTS WITH CANCER OF DIGESTIVE TRACT IN SITU.[J].Journal of Hebei North University:Medical Edition,1998(1). |
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| Authors: | Ji Hezhao |
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| Institution: | Ji Hezhao et al |
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| Abstract: | Employing immunohistochemical technique (PAP method), we analyzed the distribution of
TILs from 12 different patients with cancer of digestive tract and theexpression of CD3, CD4, CD8, CD25 and HLA - DR antigens on these lymphocytes in situ . The results showed : (1) TILs were mainly located in interstitium in tumor and rarely in parenchyma . (2) The main part in TIL was CD3 T lymphocytes, and CDt cells were less than CD8 ones in both interstitium and parenchyma , but CD4 /CD8 ratio in interstitium was higher than that in parenchyma .(3) There were TILs bearing CD25 or HLA - DR antigens in both inters titium and parenchyma in tumor tissues. As far as the possible mechanisms of these changes were also discussed in this article. |
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| Keywords: | Digestive tract TIL Immunohistochemistry |
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