Altered antioxidant enzyme profile in wound healing |
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| Authors: | Shivananda Nayak Laxminarayana Udupa Saraswati Udupa |
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| Institution: | (1) Department of Biochemistry, Kasturba Medical College, 576119 Manipal, Karnataka, India;(2) Department of Pharmacology, Kasturba Medical College, 576119 Manipal, Pin, Karnataka, India |
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| Abstract: | The effects of the alcoholic extract of the flowers ofIxora coccinea were studied on some of the antioxidant enzymes in dead space wounds created in rats. Increases in the tensile strength of
the wound and in the level of lysyl oxidase, the crucial enzyme for collagen maturation, were observed indicating a definite
prohealing action. In addition, a highly significant increase in the levels of catalase, glutathione peroxidase and glutathione
reductase was observed in the drug-treated group. Thus, the gain in tensile strength may be attributed not only to the better
cross-linking but also to the antioxidant properties of the drug. |
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| Keywords: | Antioxidant catalase glutathione peroxidase gluththione reductase Lysyl oxidase |
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