Effects of chronic ethanol exposure on renal function tests and oxidative stress in kidney |
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| Authors: | Subir Kumar Das Sowmya Varadhan L Dhanya Sukhes Mukherjee D M Vasudevan |
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| Institution: | (1) Department of Biochemistry, Amrita Institute of Medical Sciences, Elamakkara, P.O. Cochin, 682 026, India;(2) Department of Biochemistry, Agartala Govt. Medical College, Kunjaban, 799006, Agartala, India |
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| Abstract: | After administration, ethanol and its metabolites go through the kidneys and are excreted into urine. The kidney seems to
be the only vital organ generally spared in chronic alcoholics. Therefore, we investigated the multiple effects of chronic
ethanol exposure on renal function tests and on oxidative stress related parameters in the kidney. Chronic ethanol (1.6 g
ethanol/ kg body weight/ day) exposure did not show any significant change in relative weight (g/ 100g body weight) of kidneys,
serum calcium level or glutathione s-transferase activity. However, urea and creatinine concentration in serum, and TBARS
level in kidney elevated significantly, while reduced glutathione content and activities of glutathione peroxidase, glutathione
reductase and superoxide dismutase diminished significantly after 12 weeks of ethanol exposure. Catalase activity showed increased
activity after 4 weeks of ethanol exposure and decreased activity after 12 weeks of ethanol exposure. Genesis of renal ultrastructural
abnormalities after 12 weeks of ethanol exposure may be important for the development of functional disturbances. This study
revealed that chronic ethanol exposure for longer duration is associated with deleterious effects in the kidney. |
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| Keywords: | Ethanol Glutathione Kidney Oxidative stress Renal function |
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