Hypoglycemic and hypolipidemic effects of diacetodibutyl disulphide |
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| Authors: | P K Joseph R T Kasinath |
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| Institution: | (1) Department of Biochemistry, St John’s Medical College, 560 034 Bangalore, India;(2) Department of Biochemistry, Vinayaga Mission Medical College, 609609 Karaikal, Tamilnadu;(3) Present address: Department of Biochemistry, Ambedkar Medical College, 560 045 Bangalore |
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| Abstract: | The hyperlipidemia, fatty liver and the high levels of liver and kidney thiobarbituric acid reactive substances (TBARS) observed
in rats which were fed ethanol for 45 days, could be significantly reduced by feeding diacetodibutyl disulphide (DADBDS).
Ethanol-induced hypoproteinemia and the rise in serum enzymes like AST (EC 2.6.1.10), ALT (EC 2.6.1.2) and ALP (EC 3.1.3.1)
could also be ameliorated by DADBDS. Feeding of this compound to normal rats did not produce any change in serum or tissue
lipid levels or serum enzymes or tissue TBARS except a moderate reduction in serum triacyl glycerols. DADBDS feeding to rats
maintained on a high lipid diet could also reduce the serum and tissue lipid levels and also reduce the serum transaminases.
DADBDS which is an aliphatic disulphide could produce hypolipidemic effects in rats fed a single large dose of ethanol, whereas
dimenthol disulphide which is an aromatic disulphide was not useful as a hypolipidemic agent. Perhaps hypolipidemic effects
are shown only by aliphatic disulphides and not by aromatic disulphides. Feeding of 100 mg DADBDS per kg body weight to normal
fasted rats produced a mild hypoglycemia, but higher doses produced a hyperglycemic effect. This dose of DADBDS increased
the serum insulin levels and reduced blood glucose levels in fasted diabetic rats, but DADBDS feeding did not alter the serum
insulin levels in fasted normal rats. DADBDS is odourless and tasteless in 1% solution and it could be a better substitute
for garlic for hypoglycemic and hypolipidemic studies. |
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| Keywords: | Hypoglycemic effect hypolipidemic effect DADBDS garlic |
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