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Language and reading impairments are associated with increased prevalence of non-right-handedness |
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| Authors: | Filippo Abbondanza Philip S Dale Carol A Wang Marianna E Hayiou-Thomas Umar Toseeb Tanner S Koomar Karen G Wigg Yu Feng Kaitlyn M Price Elizabeth N Kerr Sharon L Guger Maureen W Lovett Lisa J Strug Elsje van Bergen Conor V Dolan J Bruce Tomblin Kristina Moll Gerd Schulte-Körne Nina Neuhoff Andreas Warnke Simon E Fisher Cathy L Barr Jacob J Michaelson Dorret I Boomsma Margaret J Snowling Charles Hulme Andrew J O Whitehouse Craig E Pennell Dianne F Newbury John Stein Joel B Talcott Dorothy V M Bishop Silvia Paracchini |
| Institution: | 1. School of Medicine, University of St Andrews, St Andrews, UK;2. Department of Speech and Hearing Sciences, University of New Mexico, Albuquerque, New Mexico, USA;3. School of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia;4. Department of Psychology, University of York, York, UK;5. Department of Education, University of York, York, UK;6. Department of Psychiatry, The University of Iowa, Iowa City, Iowa, USA;7. Division of Experimental and Translational Neuroscience, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada;8. Division of Experimental and Translational Neuroscience, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada
Program in Neuroscience and Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada Department of Physiology, University of Toronto, Toronto, Ontario, Canada;9. Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada Department of Psychology, Hospital for Sick Children, Toronto, Ontario, Canada;10. Department of Psychology, Hospital for Sick Children, Toronto, Ontario, Canada;11. Program in Neuroscience and Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada;12. Genetics and Genome Biology, Hospital for Sick Children, Toronto, Ontario, Canada Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada;13. Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands;14. Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, Ludwig-Maximilians-University Hospital Munich, Munchen, Germany;15. Julius-Maximilians-University Würzburg, Würzburg, Germany;16. Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands;17. Department of Experimental Psychology, University of Oxford, Oxford, UK;18. Department of Education, University of Oxford, Oxford, UK;19. Telethon Kids Institute, University of Western Australia, Perth, Western Australia, Australia;20. Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK;21. Department of Physiology, University of Oxford, Oxford, UK;22. Aston Brain Center, School of Life and Health Sciences, Aston University, Birmingham, UK |
| Abstract: | Handedness has been studied for association with language-related disorders because of its link with language hemispheric dominance. No clear pattern has emerged, possibly because of small samples, publication bias, and heterogeneous criteria across studies. Non-right-handedness (NRH) frequency was assessed in N = 2503 cases with reading and/or language impairment and N = 4316 sex-matched controls identified from 10 distinct cohorts (age range 6–19 years old; European ethnicity) using a priori set criteria. A meta-analysis (Ncases = 1994) showed elevated NRH % in individuals with language/reading impairment compared with controls (OR = 1.21, CI = 1.06–1.39, p = .01). The association between reading/language impairments and NRH could result from shared pathways underlying brain lateralization, handedness, and cognitive functions. |
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