Pleural fluid MDA and serum-effusion albumin gradient in pleural effusion |
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| Authors: | Manaswini Mangaraj S Kumari R Nanda M R Pattnaik P C Mohapatra |
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| Institution: | (1) Department of Biochemistry, S.C.B. Medical College, Duplex No.30, Sector-6, Bhawani constructions, Near IPSAR, Bidanasi, Cuttack. Pin, 753014, Orissa, India;(2) Department of Pulmonary Medicine, S.C.B. Medical College, Duplex No.30, Sector-6, Bhawani constructions, Near IPSAR, Bidanasi, Cuttack. Pin, 753014, Orissa, India |
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| Abstract: | Pleural fluid malondialdehyde (PMDA) and serum effusion albumin gradient(SEAG) were estimated in 60 patients of pleural effusion
of diverse etiologies. The results were compared with Light’s criteria to distinguish between transudates and exudates. The
mean PMDA level was 0.68±0.24nmol/ml and 1.17±0.25nmol/ml in transudates and exudates respectively showing a statistically
significant (p<0.05) rise in exudates in comparison to transudates. SEAG registered a significant fall in exudates (P<0.001)
when compared with transudates. PMDA revealed a positive correlation with pleural protein(r=+0.30) and a significant negative
association with SEAG (r= −0.33).Sensitivity and specificity of PMDA were better than the parameters of Light’s criteria.
Whereas SEAG documented approximately equal sensitivity, specificity, positive predictive value (PPV) and negative predictive
value (NPV) with Light’s criteria. Therefore PMDA and SEAG can be taken together in addition to Light’s criteria to strengthen
the discrimination between transudates and exudates in borderline cases of pleural effusion. |
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| Keywords: | Pleural Fluid Exudates Transudates |
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