|
|||||
|
|
| 运动性疲劳状态下大鼠心肌线粒体氧化磷酸化偶联的变化 | |
| 引用本文： | 夏云健,时庆德,蒋春笋,张勇.运动性疲劳状态下大鼠心肌线粒体氧化磷酸化偶联的变化[J].天津体育学院学报,2002,17(2):19-21. |
| 作者姓名： | 夏云健 时庆德 蒋春笋 张勇 |
| 作者单位： | 1. 江汉大学体育系,武汉,430012 2. 北京体育大学人体运动科学系,北京,100084 3. 天津体育学院运动医学研究所,天津,300381 |
| 摘 要： | 主要目的：为了探讨运动性疲劳的线粒体氧化磷酸化联机制，方法：以SD大鼠递增负荷急性力竭跑台运动为疲劳模型，分别测定了运动后即刻心肌线粒体：（1）呼吸链复合体Ⅰ Ⅲ和Ⅱ Ⅲ电子传递与质子泵出比值（H^ /2e);(2)线粒体呼吸控制，结果：线粒体苹果酸和谷氨酸为底物启动的呼吸链复合体I＋Ⅲ总H^ /2e降低了9．97％（P＜0．05），线粒体以苹果酸＋谷氨酸和琥珀酸为底物的态4呼吸均显著高于安静时，呼吸控制比均显著低于安静时（P＜0．05），结论：运动性疲劳状态下粒体氧化磷酸比偶联程度降低与质子漏增加，电子传递与质子泵出脱偶联等有关。 |
| 关 键 词： | 心肌线粒体 呼吸控制 电子传递与质子转移偶联 力竭性运动 大鼠 |
| 文章编号： | 1005-0000(2002)02-0019-03 |
| 收稿时间： | 3/1/2001 12:00:00 AM |
| 修稿时间： | 2001年3月1日 |
The Change of the Mitochondrial Oxidative Phosphorylation in Rat Heart during Exhaustive Exercise |
|
| XIA Yun-jian,SHI Qing-de,JIANG Chun-sun and ZHANG Yong.The Change of the Mitochondrial Oxidative Phosphorylation in Rat Heart during Exhaustive Exercise[J].Journal of Tianjin Institute of Physical Education,2002,17(2):19-21. | |
| Authors: | XIA Yun-jian SHI Qing-de JIANG Chun-sun and ZHANG Yong |
| Institution: | XIA Yun jian 1,SHI Qing de 2,JIANG Chun sun 1,ZHANG Yong 3 |
| Abstract: | Rats running with an incremental intensity to exhaustion was used as an experimental model The experiment was designed to determine the changes of prepared mitochondria immediately after exhaustive exercise: 1. Rate of electron transfer to proton pump of mitochondrial respiratory chain complex I+III and II + III(H +/2e). 2. The mitochondrial respiratory control. The results showed that, in exhausted rats,the parameter of complex I+III total H +/2e decreased with 9.97% (P<0.05), in the presence of Malate and Glutate, and Succinate. The rate of state 4 increased significantly in the present of Malate and Glutate, in heart (P <0.05). RCR decreased significantly in the present of Malate and Glutate and in the presence of Succinate in heart(P<0.05). The present research suggested that the increase of mitochondria proton leak and the decrease of coupling of electron transfer and proton pump may be response for the decrease of mitochondrial coupling of oxidative phosphrylation. |
| Keywords: | heart mitochondria respiratory control coupling of electron transfer and proton pump exhaustive exercise rats |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |
| 点击此处可从《天津体育学院学报》浏览原始摘要信息 | |
| 点击此处可从《天津体育学院学报》下载免费的PDF全文 | |