Relationship between the rewarding and aversive effects of morphine and amphetamine in individual subjects |
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| Authors: | Andrey Verendeev Anthony L Riley |
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| Institution: | (1) Psychopharmacology Laboratory, Department of Psychology, American University, Washington, DC 20016, USA |
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| Abstract: | Drugs of abuse have been reported to produce both rewarding and aversive effects, as evidenced by their ability to induce
both conditioned place preferences (CPPs) and conditioned taste aversions (CTAs), respectively. Although several attempts
have been made to assess the relationship between the rewarding and aversive effects of drugs in independent groups, it is
unknown to what extent (if any) preferences and aversions are related in individual animals. The present study assessed this
relationship by examining the ability of morphine (5 and 10 mg/kg) and amphetamine (3 and 5 mg/kg) to induce both place preferences
and taste aversions in the same animal, using a concurrent CTA/CPP design. There was no consistent relationship between the
ability of morphine or amphetamine at either dose to increase time spent on the drug-paired side and the ability to suppress
consumption of the drug-paired taste. These results support the position that drugs of abuse have multiple stimulus effects,
both rewarding and aversive, that condition place preferences and taste aversions independently. |
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