Effect of spironolactone on acid and alkaline phosphatase in the testes of albino rat |
| |
| Authors: | P K Singh D P Singh |
| |
| Institution: | (1) Department of Zoology, School of Life Sciences, Dr. B. R. Ambedkar University, Khandari Campus, 282002 Agra, (India) |
| |
| Abstract: | The biological activity of the mineralocorticoid antagonist, spironolactone depend upon its metabolism. In this study the
effect of diuretic drug compound spironolactone on the acid and alkaline phosphatase in the testes of albino rat. The drug
spironolactone was administered orally daily for 7th, 14th and 21st days at the dose of 100 mg/kg body weight. Among them, the side effects of drug are that the degradation of alkaline phosphatase
in the testes; while acid phosphatase increased significantly may be due to 7a-thiospironolactone is a tissue metabolite of
spironolactone and may contribute to the testicular enzymes, therapeutic actions and some other side effects. It is suggested
that the decrease and increase of alkaline and acid phosphatase in the testes of albino rat are the due to the side effects
of spironolactone drug compound. |
| |
| Keywords: | Drug Spironolactone Albino rat Acid and Alkaline Phosphatase |
| 本文献已被 SpringerLink 等数据库收录！ |
|
